ALBANY RESEARCH INSTITUTE, INC.

VSFKL2LH9328

1CYC3

2025-09-19

http://vaww.visn2.va.gov/

2024-09-23

2002-04-17

1CYC3

Active

Non-Manufacturer

2024-09-23

2029-09-23

2025-09-19

SOPHIA PALLONE

http://vaww.visn2.va.gov/

141716021

2023

31

5186265618

View File

2022

35

5186265618

View File

2021

38

5186265618

View File

V528D05015

View Award on USAspending website

AWARD

PO

15000.00

15000.00

15000.00

Department of Veterans Affairs

2010-07-20

PROFESSIONAL, ADMIN, AND MANAGEMENT SUPPORT SVC

541712: RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT BIOTECHNOLOGY)

R499: OTHER PROFESSIONAL SERVICES

2024-08-06

View on USAspending

Department of Health and Human Services

BRAIN-COMPUTER INTERFACE (BCI)-BASED IDENTIFICATION OF COLOR VISION DEFICIENCIES (CVDS) RELATED TO PARKINSON’S DISEASE (PD) - PROJECT SUMMARY/ABSTRACT PARKINSON’S DISEASE (PD) REDUCES THE VOLUNTARY MOVEMENTS, EMOTIONAL EXPRESSIONS, AND LIFE EXPECTANCY OF ABOUT ONE MILLION AMERICANS. EARLY IDENTIFICATION AND TREATMENT OF PD REDUCES COSTS AND IS ASSOCIATED WITH BETTER THERAPEUTIC OUTCOMES. THERE ARE PUTATIVE SIGNS OF PD (I.E., PRODROMAL PD) MORE THAN 20 YEARS BEFORE CLINICAL DIAGNOSIS (I.E., CLINICAL PD). GIVEN THE 60,000 TO 95,000 NORTH AMERICANS DIAGNOSED WITH PD EVERY YEAR AND THE $52 BILLION ANNUAL COST OF TREATING PD, NEW METHODS FOR EARLY IDENTIFICATION OF PD ARE URGENTLY NEEDED. COLOR VISION DEFICIENCIES (CVDS) MAY BE A VALUABLE BIOMARKER OF PRODROMAL PD. PD-RELATED CHANGES IN COLOR VISION (CV) REMAIN UNEXPLORED, HOWEVER, BECAUSE PRESENT CV ASSESSMENTS ARE NOT SENSITIVE/SPECIFIC ENOUGH, OR ARE UNSUITABLE FOR PEOPLE WITH PD-RELATED COGNITIVE IMPAIRMENTS AND/OR MOTOR DEFICITS (CIS/MDS). WE RECENTLY DEVELOPED A BRAIN-COMPUTER INTERFACE (BCI)-BASED CV ASSESSMENT THAT HAS SIGNIFICANT ADVANTAGES OVER PRESENT BEHAVIOR-BASED APPROACHES. AS A FIRST STEP TOWARDS BCI-BASED CV ASSESSMENT FOR THE IDENTIFICATION OF PRODROMAL PD, WE PROPOSE TO TEST WHETHER BCI-BASED CV ASSESSMENT CAN IDENTIFY CVDS RELATED TO CLINICAL PD. IT IS OUR HYPOTHESIS THAT THE NEW BCI-BASED METHOD HAS SUFFICIENT SENSITIVITY/SPECIFICITY AND TEST-RETEST RELIABILITY TO DETECT PD-RELATED CVDS. TO TEST THIS HYPOTHESIS, WE HAVE TWO SPECIFIC AIMS: 1. DEMONSTRATE THE ABILITY OF THE BCI-BASED CV ASSESSMENT TO MORE ACCURATELY IDENTIFY CVDS RELATED TO PD THAN PRESENT BEHAVIOR-BASED CV ASSESSMENTS. PEOPLE WITH PD AND CONTROLS WILL BE RECRUITED TO COMPLETE BCI- AND BEHAVIOR-BASED CV ASSESSMENTS. WE EXPECT THAT BCI-BASED CV ASSESSMENT WILL MORE ACCURATELY CLASSIFY INDIVIDUALS WITH PD AS HAVING CVDS (I.E., HAVE ENHANCED SENSITIVITY) AND INDIVIDUALS WITHOUT PD AS NOT HAVING CVDS (I.E., HAVE ENHANCED SPECIFICITY) THAN BEHAVIOR-BASED CV ASSESSMENTS. 2. SHOW THAT THE TEST-RETEST RELIABILITY OF BCI-BASED CV ASSESSMENT IS HIGHER THAN THE “GOLD-STANDARD” BEHAVIOR-BASED CV ASSESSMENT IN PEOPLE WITH PD. PEOPLE WITH PD AND CONTROLS WILL BE RECRUITED TO COM- PLETE BCI- AND “GOLD-STANDARD” BEHAVIOR-BASED CV ASSESSMENTS THREE TIMES EACH; PARTICIPANTS WITH PD WILL UNDERGO A NEUROLOGICAL EVALUATION. WE WILL ANALYZE THE TEST-RETEST RELIABILITY OF THE CV ASSESSMENTS AND COR- RELATIONS BETWEEN TEST-RETEST RELIABILITY AND PD STAGE, CIS, AND MDS. WE PREDICT THAT THE TEST-RETEST RELIABILITY OF THE BCI-BASED CV ASSESSMENT WILL BE HIGHER IN PEOPLE WITH PD-RELATED CIS/MDS. IN SUMMARY, THE PURPOSE OF THIS RESEARCH IS TO IDENTIFY PD-RELATED CHANGES IN CV USING A NEW BCI-BASED APPROACH; IT IS HYPOTHESIZED THAT THIS METHOD WILL HAVE ENHANCED SENSITIVITY, SPECIFICITY, AND TEST-RETEST RELIABILITY COMPARED TO PRESENT BEHAVIOR-BASED CV ASSESSMENTS. A SENSITIVE/SPECIFIC CV ASSESSMENT FOR DETECTING PD- RELATED CVDS WOULD ENABLE EARLIER DETECTION AND DIAGNOSIS OF PD AND IMPROVED MONITORING OF PD PROGRESSION. IN ADDITION, A SENSITIVE/SPECIFIC CV ASSESSMENT COULD ENABLE DETECTION OF CVDS CAUSED BY OTHER NEUROLOGICAL DISORDERS, INCLUDING MULTIPLE SCLEROSIS (MS) AND ALZHEIMER’S DISEASE (AD).

204000.00

0.00

0.00

2020-08-12

View on USAspending

Department of Health and Human Services

SPINAL EFFECTS OF CORTICAL STIMULATION: MECHANISMS AND FUNCTIONAL IMPACT

4052876.00

0.00

0.00

2021-03-31

View on USAspending

Department of Health and Human Services

DYNAMICS AND CAUSAL FUNCTIONS OF LARGE-SCALE CORTICAL AND SUBCORTICAL NETWORKS - PROJECT SUMMARY/ABSTRACT IMPROVED UNDERSTANDING OF THE BRAIN PROCESSES UNDERLYING NORMAL AND ABNORMAL FUNCTION IS NECESSARY FOR DEVISING BETTER WAYS TO DIAGNOSE, ALLEVIATE, OR CURE NEUROLOGICAL OR PSYCHIATRIC DISORDERS. IT IS CLEAR THAT EVEN FOR SIMPLE BEHAVIORS, SUCH PROCESSES DEPEND ON INTERACTIONS AMONG MULTIPLE BRAIN REGIONS. HOWEVER, THESE INTERACTIONS THEMSELVES ARE LESS WELL UNDERSTOOD. THIS INADEQUATE UNDERSTANDING OF INTER-REGIONAL INTERACTIONS IMPEDES THE GENERATION OF SUBSTANTIVE MODELS OF BRAIN FUNCTIONS AND THE NEW DIAGNOSTIC OR THERAPEUTIC POSSIBILITIES THAT SUCH MODELS COULD INTRODUCE. THESE DECIENCIES REECT IN PART THE LIMITATIONS OF THE WIDELY USED IMAGING MODALITIES. DETAILED ANALYSIS OF THE OPERATION OF A NETWORK OF BRAIN REGIONS REQUIRES COMPREHENSIVE COVERAGE, HIGH SPATIAL RESOLUTION, AND HIGH TEMPORAL RESOLUTION. HOWEVER, EXISTING TECHNIQUES EITHER LACK HIGH TEMPORAL RESOLUTION, HIGH SPATIAL RESOLUTION, OR COMPREHENSIVE COVERAGE. THUS, THEY CANNOT TRACK THE SPATIAL AND TEMPORAL PROGRESSION OF INTER-REGIONAL INTERACTIONS. INTRACRANIAL RECORDINGS USING ELECTROCORTICOGRAPHIC (ECOG) ELECTRODES PLACED ON THE BRAIN SURFACE, OR DEPTH ELECTRODES (STEREOENCEPHALOGRAPHY; SEEG) PLACED IN REGIONS AND SULCAL DEPTHS NOT ACCESSIBLE WITH ECOG, CAN PROVIDE WIDE COVERAGE AND HIGH TEMPORAL AND SPATIAL RESOLUTION. FURTHERMORE, ELECTRICAL STIMULATION THROUGH THESE ELECTRODES CAN ASSESS CAUSAL ROLES AND INTER-REGIONAL CONNECTIONS. HOWEVER, BECAUSE INTRACRANIAL ELECTRODES ARE ONLY AVAILABLE IN PATIENTS AWAITING BRAIN SURGERY, INTRACRANIAL STUDIES ARE TYPICALLY LIMITED TO SMALL NUMBERS OF SUBJECTS WITH VARIABLE ELECTRODE COVERAGE. IN THE RESEARCH PROPOSED HERE, OUR ESTABLISHED AND HIGHLY EXPERIENCED ECOG/SEEG CONSORTIUM WILL ENGAGE IN A FORMALIZED RESEARCH PROGRAM THAT SEEKS TO BEGIN TO REVEAL THE DETAILED CONNECTIVITY, CAUSALITY, AND DYNAMIC NEURAL PROCESSES SUPPORTING HUMAN SPEECH PERCEPTION. RESEARCH TO ACHIEVE OUR TWO PROJECT AIMS WILL TAKE FULL ADVANTAGE OF THE OPPORTUNITIES AFFORDED BY INTRACRANIAL ELECTRODES. THE PROPOSED WORK WILL MAKE USE OF AN ESTABLISHED INTERDISCIPLINARY INTRACRANIAL CONSORTIUM, WITH FOUR DATA COLLECTION SITES PROVIDING ACCESS TO DOZENS OF SUBJECTS PER YEAR. THE CONSORTIUM WILL APPLY ITSELF TO ANSWERING NEW QUESTIONS ABOUT DYNAMIC INTER-AREAL FUNCTION UNDERLYING SPEECH PERCEPTION. IF SUCCESSFUL, THE PROPOSED WORK SHOULD NOT ONLY ADD NEW NEUROSCIENTIC UNDERSTANDING, BUT ALSO FORMALLY VALIDATE A CONSORTIUM STRUCTURE AS A MODEL FOR INTRACRANIAL RESEARCH.

1426088.88

0.00

0.00

2020-08-14

View on USAspending

Department of Health and Human Services

CENTER FOR ADAPTIVE NEUROTECHNOLOGIES

12516786.13

0.00

0.00

2010-05-03

View on USAspending

Department of Health and Human Services

IRON IN THE PATHOGENESIS OF FRIEDREICH'S ATAXIA

1332892.00

0.00

0.00

2012-01-23

Prog Related

113 HOLLAND AVE, ALBANY, NY, 12208

Safety

Partial

14-1716021

Government Instrumentality, Title-Holding Corporation, Charitable Organization, Agricultural Organization, Board of Trade, Pleasure, Recreational, or Social Club, Fraternal Beneficiary Society, Order or Association, Voluntary Employees' Beneficiary Association (Non-Govt. Emps.), Domestic Fraternal Societies and Associations, Teachers Retirement Fund Assoc., Benevolent Life Insurance Assoc., Burial Association, Credit Union, Mutual Insurance Company or Assoc. Other Than Life or Marine, Corp. Financing Crop Operations, Supplemental Unemployment Compensation Trust or Plan, Employee Funded Pension Trust (Created Before 6/25/59), Post or Organization of War Veterans, Legal Service Organization, Black Lung Trust, Multiemployer Pension Plan, Veterans Assoc. Formed Prior to 1880, Trust Described in Sect. 4049 of ERISA, Title Holding Co. for Pensions, etc., State-Sponsored High Risk Health Insurance Organizations, State-Sponsored Workers' Compensation Reinsurance, ACA 1322 Qualified Nonprofit Health Insurance Issuers, Apostolic and Religious Org. (501(d)), Cooperative Hospital Service Organization (501(e)), Cooperative Service Organization of Operating Educational Organization (501(f)), Child Care Organization (501(k)), Charitable Risk Pool, Qualified State-Sponsored Tuition Program, 4947(a)(1) - Private Foundation (Form 990PF Filer)

1989-07

Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)