THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.

GMR5T8P487D7

4KPU7

2025-01-17

http://nysbc.org/

2024-01-19

2006-10-18

4KPU7

Active

Non-Manufacturer

2024-03-01

2029-01-19

2025-01-17

JEFFREY KIEFT

+1 212-939-0660

+1 212-939-0863

134043587

2011

67

2129390660

View File

75N91018P00773

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AWARD

PURCHASE ORDER

Department of Health and Human Services

2018-09-24

202965.00

202965.00

405610.00

SERVICES TO GENERATE HIGH RESOLUTION X-RAY CRYSTAL STRUCTURES OF THE EXTRACELLULAR DOMAINS OF CHIMERIC ANTIGEN RECEPTOR (CAR) PROTEINS AND OTHER IMMUNOLOGICALLY RELEVANT SURFACE RECEPTORS AND CO-RECEPTORS, AND THEIR INTERACTIONS WITH THEIR TUMOR ANTIGENS, IN SUPPORT OF THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, NATIONAL CANCER INSTITUTE (NCI), CENTER FOR CANCER RESEARCH (CCR)

541990: ALL OTHER PROFESSIONAL, SCIENTIFIC, AND TECHNICAL SERVICES

B529: SPECIAL STUDIES/ANALYSIS- SCIENTIFIC DATA

W911SR14C0047

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AWARD

DEFINITIVE CONTRACT

Department of Defense

2014-09-26

1389584.53

1439039.60

1439039.60

IGF::OT::IGF BROAD AGENCY ANNOUNCEMENT (BAA) ENTITLED "ACETYLCHOLINESTERASE BY NUCLEAR MAGNETIC RESONANCE (NMR)AND X-RAY"

541712: RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT BIOTECHNOLOGY)

AD21: R&D- DEFENSE OTHER: SERVICES (BASIC RESEARCH)

W911SR12C0006

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AWARD

DCA

Department of Defense

2012-08-16

DUAL USE STRUCTURAL BIOLOGICAL PIPELINE, INCREMENTAL FUNDING

541712: RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT BIOTECHNOLOGY)

AD21: R&D- DEFENSE OTHER: SERVICES (BASIC RESEARCH)

2024-08-14

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Department of Health and Human Services

FUNCTIONAL IMPLICATIONS OF STRUCTURAL HETEROGENEITY IN A VIRAL RNA TRANSLATION INITIATION ELEMENT - PROJECT SUMMARY RNA VIRUSES ARE AN EMERGING HEALTH THREAT, EVOLVING RAPIDLY TO PROLIFERATE AND SPREAD. WITHIN THESE VIRUSES ARE STRUCTURED RNA ELEMENTS THAT FACILITATE INFECTION AND VIRUS SURVIVAL. INTERNAL RIBOSOME ENTRY SITES (IRESS) ARE A TYPE OF RNA STRUCTURE FOUND WITHIN RNA VIRUSES THAT FACILITATE INFECTION BY ENABLING INITIATING TRANSLATION ON THE VIRAL GENOME WHEN CELLULAR TRANSLATION IS REPRESSED DURING INFECTION. THE HEPATITIS C VIRUS (HCV) CONTAINS AN IRES THAT HAS BEEN EXTENSIVELY STUDIED, DEMONSTRATING A MECHANISM OF INITIATION INTIMATELY LINKED TO RNA ARCHITECTURE. THE HCV IRES CONSISTS OF A LARGE, MULTI-DOMAIN STRUCTURE THAT INTERACTS DIRECTLY WITH THE SMALL RIBOSOMAL SUBUNIT (40S) AND EUKARYOTIC INITIATION FACTOR 3 (EIF3) TO FORM AN INITIATION COMPLEX. IN TANDEM WITH MECHANISTIC AND STRUCTURAL STUDIES OF THE HCV IRES, A HANDFUL OF OTHER VIRUSES WITH A SIMILAR STRUCTURE– TERMED HCV-LIKE IRESS – HAVE BEEN SPORADICALLY IDENTIFIED THROUGH SEQUENCE HOMOLOGY. DESPITE DEMONSTRATING NOTABLE STRUCTURAL DIVERSITY, HCV-LIKE IRESS ARE INFERRED TO SHARE THE SAME MECHANISM. I HYPOTHESIZE THAT THERE ARE DISTINCT STRUCTURAL SUBGROUPS WITHIN THE HCV CLASS OF IRESS AND BETWEEN THESE SUBGROUPS THERE ARE DIFFERENCES IN THEIR INITIATION COMPLEX COMPONENTS AND INTERMOLECULAR INTERACTIONS. IN MY FIRST AIM, I WILL DEFINE THE STRUCTURAL DIVERSITY OF HCV-LIKE IRESS AS A CLASS USING COMPUTATIONAL AND BIOCHEMICAL METHODS. I HAVE PERFORMED A STRUCTURE ALIGNMENT-BASED SEARCH TO MINE THE NCBI VIRUS DATABASE, REVEALING 178 UNIQUE PUTATIVE IRESS. I WILL USE COMPUTATIONAL METHODS TO STRUCTURALLY CHARACTERIZE DISCRETE REGIONS OF THESE PUTATIVE IRESS THAT DIFFER BETWEEN SUBGROUPS. PREDICTED IRES ARCHITECTURE AND FUNCTION WILL BE VALIDATED BIOCHEMICALLY TO LINK STRUCTURAL HETEROGENEITY WITH TRANSLATION INITIATION EFFICIENCY. FOR AIM 2, I WILL UNCOVER THE MECHANISTIC BASIS UNDERLYING THE STRUCTURAL AND FUNCTIONAL DIFFERENCES AMONG HCV-LIKE IRES BY INVESTIGATING INITIATION COMPLEX FORMATION. I WILL DETERMINE BOTH THE COMPOSITION OF THESE IRES INITIATION COMPLEXES AND THE AFFINITY OF THE IRES FOR EACH COMPONENT WITHIN THE COMPLEX. SELECT IRES INITIATION COMPLEXES WILL BE VISUALIZED USING CRYO-ELECTRON MICROSCOPY, POTENTIALLY REVEALING NOVEL INTERMOLECULAR INTERACTIONS. THE WORK OUTLINED IN THIS PROPOSAL WILL ENHANCE UNDERSTANDING OF THE RELATIONSHIP BETWEEN HCV-LIKE IRES STRUCTURE AND FUNCTION. FURTHER, THIS RESEARCH WILL PROVIDE INSIGHT INTO MECHANISMS OF EUKARYOTIC INITIATION THAT COULD BE LEVERAGED FOR USE IN VACCINES AND THERAPEUTICS TO COMBAT RNA VIRUSES.

48974.00

0.00

0.00

2024-06-27

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Department of Health and Human Services

NCCAT: NATIONAL CENTER FOR CRYOEM ACCESS AND TRAINING - PROJECT SUMMARY/ABSTRACT THE NATIONAL CENTER FOR CRYOEM ACCESS AND TRAINING (NCCAT) ENABLES USERS TO SOLVE MACROMOLECULAR STRUCTURES RAPIDLY AND TO THE HIGHEST POSSIBLE RESOLUTION USING CRYO-ELECTRON MICROSCOPY (CRYOEM) METHODS. WE PROPOSE TO CONTINUE TO: (1) PROVIDE ACCESS TO STATE-OF-THE-ART EQUIPMENT, (2) MAINTAIN A HIGHLY QUALIFIED TECHNICAL TEAM OFFERING DIRECT SUPPORT, GUIDANCE, AND ASSISTANCE, (3) OPERATE A COMPREHENSIVE CROSS-TRAINING PROGRAM FOR USERS ACROSS DIVERSE SKILL LEVELS AND CAREER GOALS, AND (4) ENSURE EQUAL OPPORTUNITY NATIONWIDE ACCESS THROUGH AN OPEN AND TRANSPARENT APPLICATION PROCESS. NCCAT IS HOUSED AT THE SIMONS ELECTRON MICROSCOPY CENTER (SEMC) WITHIN THE NEW YORK STRUCTURAL BIOLOGY CENTER (NYSBC) IN NEW YORK CITY. NCCAT’S ESTABLISHED OPERATIONS AT SEMC AND NYSBC BENEFIT FROM THE VIBRANT ENVIRONMENT AND EXPERTISE OF EXISTING HIGHLY TRAINED STAFF. NCCAT OCCUPIES CUSTOM-BUILT SPACE THAT PROVIDES OPTIMAL, ENVIRONMENTALLY STABLE CONDITIONS. THE PRIMARY INSTRUMENTATION CONSISTS OF 4 DEDICATED TITAN KRIOS TEMS, EACH EQUIPPED WITH DIRECT DETECTORS AND ENERGY FILTERS; 1 (SOON TO BE 3) DEDICATED GLACIOS TEMS, EACH EQUIPPED WITH DIRECT DETECTORS, AND 3 SIDE ENTRY SCREENING MICROSCOPES (1 OF WHICH IS DEDICATED TO NCCAT) EQUIPPED WITH CMOS CAMERAS. THESE ARE AUGMENTED BY ALL ANCILLARY EQUIPMENT NEEDED FOR THE CRYOEM WORKFLOW, INCLUDING SEVERAL CLASSES OF VITRIFICATION AND SAMPLE PREPARATION EQUIPMENT. NCCAT PROVIDES ON-SITE, REMOTE-ACCESS, AND MAIL-IN DATA COLLECTION SERVICES WITH FAIR AND EQUAL ACCESS TO A NATIONWIDE USER BASE, AND WE GUIDE AND ASSIST USERS WITH ALL ASPECTS OF CRYOEM, INCLUDING SAMPLE PREPARATION, DATA COLLECTION, DATA PROCESSING, DATA ANALYSIS, AND STRUCTURE REFINEMENT. BY PROVIDING USERS WITH ACCESS TO STREAMLINED WORKFLOWS AND RESOURCES, NCCAT ALLOWS RESEARCHERS TO COLLECT HIGH-QUALITY DATA QUICKLY AND EFFICIENTLY, WHICH WILL LEAD TO FASTER PROGRESS IN STRUCTURAL BIOLOGY RESEARCH. NCCAT’S TRAINING PROGRAM ENCOMPASSES A FULL RANGE OF EXPECTATIONS, FROM THE BASICS REQUIRED TO ENSURE THAT USERS PRODUCE VALID STRUCTURES, THROUGH MORE DETAILED TRAINING FOR USERS SEEKING INDEPENDENCE, TO THOSE EXPECTED TO RUN CRYOEM RESEARCH LABORATORIES. A WELL-ESTABLISHED GRID PREPARATION AND SCREENING SERVICE PROGRAM SUPPORTS NEW PRACTITIONERS OF CRYOEM METHODS AND/OR LABORATORIES THAT LACK LOCAL FACILITIES AND RESOURCES TO OPTIMIZE SAMPLE AND GRID PREPARATION CONDITIONS AND, WHEN POSSIBLE, OBTAIN PRELIMINARY CRYOEM PROCESSED DATA. WE PROPOSE TO BE TRANSFORMATIVE BY SETTING THE STANDARD FOR ACCESS AND TRAINING TO CRYOEM TECHNOLOGY. BY FACILITATING THE SHIFT FROM THE CURRENT MODEL OF ISOLATED AND EXPENSIVE FACILITIES TO A UNIFIED AND MORE EFFICIENT CENTER, WE WILL ENABLE SCIENCE OF THE HIGHEST QUALITY AND VALUE AND THEREFORE PROVIDE ESSENTIAL FOUNDATIONAL KNOWLEDGE NEEDED TO DEVELOP NEW THERAPIES, DIAGNOSTICS, AND CLINICAL PRACTICES TO BETTER HUMAN HEALTH.

7709519.00

0.00

0.00

2023-09-12

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Department of Health and Human Services

ACQUISITION OF AN 800 MHZ NMR SPECTROMETER CONSOLE AND PROBES - FUNDING IS REQUESTED TO OBTAIN A BRUKER BIOSPIN NMR AVANCE NEO 800 MHZ CONSOLE AND ASSOCIATED COMPONENTS, INCLUDING BMPC-2 MAGNET CONTROL SYSTEM, CRYOPLATFORM/5, MASIII PNEUMATIC CONTROL UNIT, TCI-H&F TRIPLE-RESONANCE CRYOPROBE, MAS TRI-GAMMA 1.9 MM SOLID-STATE PROBE, AND MAS 3.2 MM SOLID-STATE CRYOPROBE, TO BE INSTALLED ON AN EXISTING BRUKER BIOSPIN 800 MHZ NMR MAGNET SYSTEM. THE PRESENT NMR AVANCE I CONSOLE AND TCI CRYOPROBE/1 WERE INSTALLED 2003 AND 2004 AND WERE DECLARED BY BRUKER BIOSPIN TO HAVE REACHED “END OF SERVICE” (EOS) IN 2018 AND 2019, RESPECTIVELY. THE REQUESTED INSTRUMENTATION PROVIDES ENHANCED SENSITIVITY AND CAPABILITIES FOR MODERN NMR EXPERIMENTS, INCLUDING TEMPERATURE-LOCKING, NON-UNIFORM SAMPLING, COMPLEX WAVEFORM GENERATION, MAGIC-ANGLE SPINNING (MAS) SOLID-STATE NMR SPECTROSCOPY, AND ADVANCED CRYOGENIC PROBE DESIGN FOR BOTH SOLUTION AND SOLID-STATE MAS APPLICATIONS. THE REQUESTED INSTRUMENTATION IS ESSENTIAL TO THE OVER-RIDING PURPOSE OF THE NEW YORK STRUCTURAL BIOLOGY CENTER (NYSBC), A CONSORTIUM OF NINE RESEARCH INSTITUTIONS IN NEW YORK STATE, TO SUPPORT THE SPECIFIC AIMS OF THE NIH-FUNDED RESEARCH OF THE MAJOR AND MINOR USERS OF THE SPECTROMETER. RESEARCH CONDUCTED ON THE 800 MHZ NMR SPECTROMETER RANGES FROM FUNDAMENTAL STUDIES OF STRUCTURE/FUNCTION OF BIOMOLECULES, TO ELUCIDATION OF MECHANISMS OF PATHOGENESIS, TO DISCOVERY OF NOVEL LEAD COMPOUNDS TO PHARMACEUTICAL APPLICATIONS. THE REQUESTED INSTRUMENTATION WILL DRAMATICALLY ENHANCE THE CAPACITY OF THE 800 MHZ NMR SPECTROMETER TO CONDUCT THIS RESEARCH.

1995725.00

0.00

0.00

2023-06-28

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Department of Health and Human Services

MECHANISMS OF VIRAL RNA MATURATION BY CO-OPTING CELLULAR EXONUCLEASES - PROJECT SUMMARY AS OBLIGATE CELLULAR PARASITES, VIRUSES EMPLOY A VARIETY OF STRATEGIES TO CO-OPT THE HOST CELL’S MACHINERY, USING IT TO GENERATE THE MOLECULES NEEDED FOR SUCCESSFUL INFECTION. MANY OF THESE STRATEGIES INVOLVE VIRAL RNA THAT FORMS SPECIFIC STRUCTURES ABLE TO INTERACT WITH AND MANIPULATE CELLULAR COMPONENTS. AN IMPORTANT EXAMPLE IS FOUND IN THE MOSQUITO-BORNE FLAVIVIRUSES, WHICH CO-OPT A CELLULAR EXORIBONUCLEASE AND USE IT TO GENERATE PATHOGENICALLY-IMPORTANT NON-CODING RNAS. SPECIFICALLY, THE 5’3’ EXORIBONUCLEASE XRN1 IS RECRUITED TO THE GENOMIC RNA, PROCESSIVELY DEGRADES IT, BUT THEN HALTS AT SPECIFIC LOCATIONS IN THE GENOME. THIS PROGRAMMED “EXORIBONUCLEASE RESISTANCE” DEPENDS ON SPECIFIC THREE-DIMENSIONAL RNA STRUCTURES THAT ARE EMBEDDED IN THE FLAVIVIRAL RNA. THE EXORIBONUCLEASE-RESISTANT RNAS (XRRNAS) OF THE MOSQUITO-BORNE FLAVIVIRUSES ARE THE PROTOTYPES OF THIS PROCESS AND WE HAVE LEARNED MUCH BY STUDYING THEM. HOWEVER, IT IS NOW CLEAR THAT THE STRATEGY OF CO- OPTING AND EXPLOITING CELLULAR EXORIBONUCLEASES IS NOT LIMITED TO THESE VIRUSES, BUT MAY BE WIDESPREAD. EVIDENCE SUGGESTS THAT DIVERSE VIRUSES USE DIFFERENT TYPES OF EXORIBONUCLEASE-RESISTANT RNA ELEMENTS AS A MEANS TO PROCESS LONG PRECURSOR RNAS INTO SHORTER, BIOLOGICALLY ACTIVE RNAS. HOWEVER, DESPITE THE EMERGING IMPORTANCE OF THESE NOVEL EXORIBONUCLEASE- RESISTANT RNA STRUCTURES AND THE MECHANISMS THEY PERFORM, WE KNOW ALMOST NOTHING ABOUT THEM. AMONG THE BURNING FUNDAMENTAL QUESTIONS: DO ALL OF THESE PUTATIVE XRN1-RESISTANT ELEMENTS USE A SIMILAR MECHANISM? DESPITE NO OBVIOUS SEQUENCE SIMILARITY, ARE THEY ALL FOLDED RNAS? ARE THEY ALL RNA STRUCTURE-DRIVEN, OR DO SOME REQUIRE BOUND PROTEINS? ARE THE FOLDS OF THESE DIFFERENT RNAS SIMILAR, OR HAS NATURE EVOLVED MANY WAYS TO ACHIEVE THE GOAL OF BLOCKING PROGRESSION OF AN EXORIBONUCLEASE? OUR UNDERSTANDING OF THESE PROCESSES IN DIVERSE VIRUSES IS HAMPERED BY A LACK OF BASIC INFORMATION ABOUT VARIOUS XRRNA STRUCTURES. THE FOCUS OF THIS PROPOSAL IS THEREFORE TO DRIVE THE FIELD FORWARD BY STUDYING SEVERAL UNEXPLORED EXAMPLES OF XRRNAS. WE AIM TO GAIN INSIGHT INTO THE BREADTH AND DIVERSITY OF THE EXORIBONUCLEASE RESISTANCE PHENOMENON, TO DISCOVER FUNDAMENTAL PRINCIPLES OF EXORIBONUCLEASE RESISTANCE THAT MAY BE APPLICABLE ACROSS THE LARGER VIRAL WORLD, AND TO DEVELOP NEW TECHNOLOGY TO ENABLE US TO FIND OR PREDICT EXORIBONUCLEASE STRUCTURES IN OTHER VIRUSES AND CONTEXTS. WE PROPOSE THREE AIMS: (1) DETERMINE THE ESSENTIAL SEQUENCES, STRUCTURAL DETERMINANTS, AND MECHANISTIC CHARACTERISTICS OF EXORIBONUCLEASE RESISTANCE BY A DIVERSE SET OF FLAVIVIRAL RNAS. (2) DEFINE SEQUENCES AND STRUCTURES OF RNAS FROM THE DIANTHOVIRUSES AND RIFT VALLEY FEVER VIRUS THAT CONFER EXORIBONUCLEASE RESISTANCE, AND (3) DEVELOP A SYNTHETIC EXPANDED PHYLOGENY OF XRN1-RESISTANT RNAS AND USE THIS TO COMPUTATIONALLY SEARCH FOR UNIDENTIFIED RESISTANT RNAS IN OTHER VIRUSES. OUR APPROACH IS TO COMBINE BIOCHEMICAL ASSAYS THAT ARE UNIQUE TO OUR LAB AND THAT COMPRISE A COMPREHENSIVE SET OF TOOLS FOR EXPLORING THESE RNAS, STRUCTURAL BIOLOGY TO INCLUDE X-RAY CRYSTALLOGRAPHY, AND IN VITRO SELECTIONS COUPLED WITH COMPUTATIONAL TOOLS. THE RESEARCH DESCRIBED HERE WILL CONTRIBUTE SIGNIFICANT BASIC KNOWLEDGE REGARDING AN IMPORTANT MOLECULAR PROCESS OF BROAD APPLICABILITY TO VIRAL DISEASE, A NECESSARY STEP BETWEEN THE DISCOVERY OF A MECHANISM AND THE TARGETING OF IT FOR THERAPEUTIC INTERVENTION.

3429334.00

0.00

0.00

2022-06-27

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Department of Health and Human Services

RM1 CENTER ON MACROMOLECULAR DYNAMICS BY NMR SPECTROSCOPY AT THE NEW YORK STRUCTURAL BIOLOGY CENTER (COMD/NMR) - THIS PROPOSAL DESCRIBES THE MISSION AND STRATEGIC PLANS FOR OF A BIOMEDICAL TECHNOLOGY DEVELOPMENT AND DISSEMINATION CENTER (RM1) ENTITLED CENTER ON MACROMOLECULAR DYNAMICS BY NMR SPECTROSCOPY (COMD/NMR). LOCATED AT THE NEW YORK STRUCTURAL BIOLOGY CENTER, COMD/NMR HAS DEVELOPED NEW EXPERIMENTAL AND COMPUTATIONAL TECHNIQUES IN NMR SPECTROSCOPY, INCLUDING BOTH STRUCTURE AND DYNAMICS METHODS FOR BOTH SOLUTION AND SOLID STATE NMR. HERE WE FOCUS MAINLY ON SPIN RELAXATION METHODS, WHICH HAVE ALREADY HAD GREAT IMPACT FOR CHARACTERIZING PROTEIN AND NUCLEIC ACID CONFORMATIONAL DYNAMICS DURING BIOLOGICAL PROCESSES INCLUDING LIGAND RECOGNITION, ALLOSTERISM, OLIGOMERIZATION, CATALYSIS, AND FOLDING. THE CENTRAL CHALLENGE ADDRESSED BY COMD/NMR IS TO BREAK DOWN THE HIGH ACTIVATION BARRIER FOR NEW USERS TO APPLY ADVANCED NMR SPECTROSCOPIC AND COMPUTATIONAL METHODS AND THEREBY MAKE SOPHISTICATED NMR APPROACHES AVAILABLE TO A WIDE BIOLOGICAL RESEARCH COMMUNITY. TO DO SO, COMD/NMR ADDRESSES FOUR PRIMARY OBSTACLES. (I) BECAUSE DYNAMICS PROBLEMS FOR BIOPOLYMERS ARE FREQUENTLY UNDERDETERMINED, WE DEVELOP INCISIVE NEW EXPERIMENTS, PULSE SEQUENCES AND COMPUTATIONAL METHODS. (II) BECAUSE ACCESS TO ADVANCED NMR INSTRUMENTS CAN BE A LIMITATION FOR MANY USERS, WE PROVIDE ACCESS TO A RANGE OF ENABLING NMR INSTRUMENTATION, INCLUDING NMR SPECTROMETERS AT MULTIPLE STATIC MAGNETIC FIELDS, A RANGE OF MODERN PROBES, DYNAMIC NUCLEAR POLARIZATION, RAPID-FREEZE-QUENCH, HIGH-PRESSURE EQUIPMENT, AND FIELD CYCLING RELAXOMETRY, ALL IN A WELL MAINTAINED, STAFF SUPPORTED, AND MULTIUSER ENVIRONMENT. (III) BECAUSE TRANSFER OF TECHNOLOGY TO BIOLOGISTS (AND EVEN TO NMR SPECTROSCOPISTS) HAS BEEN HINDERED BY THE COMPLEXITY OF THE METHODS, AND SINCE TIME EFFICIENT USE OF THE INSTRUMENTS IS CRUCIAL, WE DEVELOP ROBUST EFFICIENT PIPELINES TO FACILITATE EXPERIMENTAL PLANNING, DATA ACQUISITION AND ANALYSIS BY NON- SPECIALISTS. (IV) BECAUSE BIOLOGISTS WITH RESEARCH PROGRAMS THAT WOULD BENEFIT FROM THESE METHODS ARE UNAWARE OF THE POTENTIAL, WE ENGAGE IN COMMUNITY OUTREACH AND EDUCATION. A UNIQUE STRENGTH OF OUR PROGRAM IS THE INTEGRATION OF FOREFRONT SOLID STATE NMR, SOLUTION NMR AND COMPUTATIONAL EXPERTS, AND THIS PROPOSAL HIGHLIGHTS SYNERGY ACROSS THESE APPROACHES. ADDITIONALLY, BEING SITUATED WITHIN THE NYSBC, WE HAVE EXCELLENT PARTNERSHIPS WITH X-RAY DIFFRACTION, CRYO EM, AND MEMBRANE PROTEIN PRODUCTION TECHNOLOGIES. GIVEN THE DEMANDING NATURE OF THE THREE TECHNOLOGY DEVELOPMENT PROJECTS (TDPS) PROPOSED HEREIN, WE HAVE IDENTIFIED A NUMBER OF TECHNOLOGY PARTNERSHIP PROJECTS (TPPS), ENGAGING WORLD LEADERS IN ASPECTS OF NMR WHO HAVE INDICATED THEIR EAGERNESS TO PARTNER WITH US. TECHNOLOGY DEVELOPMENT PROCEEDS MOST EFFECTIVELY WHEN DRIVEN BY EXCITING AND CHALLENGING APPLICATIONS; ACCORDINGLY, COMD/NMR WILL WORK CLOSELY WITH OUTSTANDING LOCAL AND NATIONAL INVESTIGATORS THROUGH COLLABORATIVE AND SERVICE PROJECTS (CSP), DRIVING BIOMEDICAL PROJECTS (DBB) AND COMMUNITY ENGAGEMENT (CE) ACTIVITIES, INCLUDING EXTENSIVE TRAINING AND DISSEMINATION PROGRAMS. THROUGH ITS VARIOUS COMPONENTS, COMD/NMR WILL IMPACT A DIVERSE RANGE OF BIOLOGICAL RESEARCH WITH HUMAN HEALTH RELATEDNESS, INCLUDING DEGENERATIVE DISEASES, METABOLIC DISORDERS, AND CANCER.

5171602.00

0.00

0.00

13-4043587

Government Instrumentality, Title-Holding Corporation, Charitable Organization, Agricultural Organization, Board of Trade, Pleasure, Recreational, or Social Club, Fraternal Beneficiary Society, Order or Association, Voluntary Employees' Beneficiary Association (Non-Govt. Emps.), Domestic Fraternal Societies and Associations, Teachers Retirement Fund Assoc., Benevolent Life Insurance Assoc., Burial Association, Credit Union, Mutual Insurance Company or Assoc. Other Than Life or Marine, Corp. Financing Crop Operations, Supplemental Unemployment Compensation Trust or Plan, Employee Funded Pension Trust (Created Before 6/25/59), Post or Organization of War Veterans, Legal Service Organization, Black Lung Trust, Multiemployer Pension Plan, Veterans Assoc. Formed Prior to 1880, Trust Described in Sect. 4049 of ERISA, Title Holding Co. for Pensions, etc., State-Sponsored High Risk Health Insurance Organizations, State-Sponsored Workers' Compensation Reinsurance, ACA 1322 Qualified Nonprofit Health Insurance Issuers, Apostolic and Religious Org. (501(d)), Cooperative Hospital Service Organization (501(e)), Cooperative Service Organization of Operating Educational Organization (501(f)), Child Care Organization (501(k)), Charitable Risk Pool, Qualified State-Sponsored Tuition Program, 4947(a)(1) - Private Foundation (Form 990PF Filer)

1999-07

Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)

2020-04-27

Paid in Full

100

1081300

1081300

Unanswered

Unknown/NotStated

Unanswered

Unanswered

1094606

2021-02-18

Paid in Full

100

1025763

1025763

White

Not Hispanic or Latino

Female Owned

Non-Veteran

1039952.72