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  5. STEM CULTURES LLC

STEM CULTURES LLC

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Company Details

Name: STEM CULTURES LLC
Jurisdiction: New York
Legal type: FOREIGN LIMITED LIABILITY COMPANY
Status: Active
Date of registration: 23 Oct 2012 (13 years ago)
Entity Number: 4311900
ZIP code: 12866
County: Saratoga
Place of Formation: Delaware
Address: 553 CRESCENT AVENUE, SARATOGA SPRINGS, NY, United States, 12866

DOS Process Agent

Name Role Address
THE LLC DOS Process Agent 553 CRESCENT AVENUE, SARATOGA SPRINGS, NY, United States, 12866

U.S. Small Business Administration Profile

The U.S. Small Business Administration (SBA) helps Americans start, grow, and build resilient businesses.

Note: SBA was created in 1953 as an independent agency of the federal government to aid, counsel, assist and protect the interests of small business concerns; preserve free competitive enterprise; and maintain and strengthen the overall economy of our nation. SBA reviews Congressional and testifies on behalf of small businesses. It assesses the impact of regulatory burden on small businesses.

Website:
www.stemcultures.com
E-Commerce Website:
https://www.stemcultures.com
Phone Number:
315-427-0652
E-mail Address:
krissyroberts@stemcultures.com
Contact Person:
KRISTINA ROBERTS
Ownership and Self-Certifications:
Self-Certified Small Disadvantaged Business
User ID:
P1991711

Unique Entity ID

A UEI is a government-provided number, like a tax ID number, that’s used to identify businesses eligible for federal grants, awards and contracts.

Note: In April 2022, the federal government replaced its old identifier of choice, the Data Universal Numbering System (DUNS) number, with a government-issued UEI. Now all the federal government’s Integrated Award Environment systems use UEI numbers instead of DUNS numbers. So any entity doing business with the federal government must register for a UEI.

Unique Entity ID:
P4JPYMXCHB43
CAGE Code:
6NPM8
UEI Expiration Date:
2026-04-11

Business Information

URL:
www.stemcultures.com
Activation Date:
2025-04-16
Initial Registration Date:
2015-10-21

Commercial and government entity program

The The Commercial And Government Entity Code (CAGE) is assigned by the Department of Defense's Defense Logistics Agency (DLA) and represents your company's physical address for GSA's mailings, payments, and administrative records.

Note: A CAGE Code enables a company to contract with the U.S. government, allowing bid on government contracts and to receive government payments. Also for business this means that it's a Verified business entity and Has a validated physical address.

CAGE number:
6NPM8
Status:
Active
Type:
Non-Manufacturer
CAGE Update Date:
2024-06-04
CAGE Expiration:
2029-06-04
SAM Expiration:
2025-06-03

Contact Information

POC:
KRISTINA M. ROBERTS
Phone:
+1 315-427-0652

Filings

Filing Number Date Filed Type Effective Date
121023000544 2012-10-23 APPLICATION OF AUTHORITY 2012-10-23

USAspending Awards / Contracts

Procurement Instrument Identifier:
75N95020P00459
Link:
View Award on USAspending website
Award Or Idv Flag:
AWARD
Award Type:
PURCHASE ORDER
Action Obligation:
0.00
Base And Exercised Options Value:
0.00
Base And All Options Value:
0.00
Awarding Agency Name:
Department of Health and Human Services
Performance Start Date:
2020-08-19
Description:
CUSTOM GROWTH FACTOR-RELEASING BEADS PURCHASE
Naics Code:
325414: BIOLOGICAL PRODUCT (EXCEPT DIAGNOSTIC) MANUFACTURING
Product Or Service Code:
6550: IN VITRO DIAGNOSTIC SUBSTANCES, REAGENTS, TEST KITS AND SETS

USAspending Awards / Financial Assistance

Date:
2023-03-09
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
CONTROLLED-RELEASE MICROBEADS TO REPLACE GROWTH FACTORS IN FETAL BOVINE SERUM - SCIENTIFIC ABSTRACT: THE FREQUENT USE OF FETAL BOVINE SERUM (FBS) TO SUPPORT CELL CULTURES IS CHALLENGED BY LOT-TO-LOT VARIABILITY, SUPPLY CONSTRAINTS, PATHOGEN CONTAMINANTS AND ETHICAL QUESTIONS. THESE ISSUES HAVE INCREASED SIGNIFICANCE DUE TO THE BURGEONING USE OF FBS IN CELL RESEARCH AND THERAPY DEVELOPMENT. FBS HAS BEEN USED FOR OVER A CENTURY TO CULTURE CELLS, BUT WITH THE NEED TO DEFINE CULTURE CONDITIONS FOR EFFICIENT MANUFACTURING, ALONG WITH MODERN APPROACHES TO CONTROL DELIVERY OF KEY MOLECULES, MANY OF THE PROBLEMS ASSOCIATED WITH FBS USE CAN NOW BE ALLEVIATED. THE NEED TO REDUCE ANIMAL PRODUCTS IS CRITICALLY IMPORTANT, AS IS THE NEED TO USE HUMAN GROWTH FACTORS TO OPTIMIZE HUMAN CELL GROWTH. THE COMPANY STEMCULTURES SPECIALIZES IN CONTROLLING THE GROWTH FACTOR (GF) COMPONENT OF CELL CULTURE MEDIA. OUR GOAL IS TO REPLACE FBS GFS WITH A BIOENGINEERED DISCTM (DEFINED INSERT FOR SUSTAINABLE CULTURE) DEVICE PROVIDING CONTROLLED-RELEASE HUMAN RECOMBINANT GFS. THE ADVANCED CELL MANUFACTURING DISCTM DEVICE WILL ADDRESS CONCERNS ABOUT FBS AND IMPROVE THE REPRODUCIBILITY OF CELL PRODUCTION. IN THIS APPLICATION WE WILL DEVELOP A DISCTM DEVICE FOR GROWTH OF HUMAN RETINAL PIGMENT EPITHELIAL (RPE) CELLS. HUMAN RPE WAS SELECTED AS A TESTBED FOR FBS REPLACEMENT AS THESE CELLS ARE A VANGUARD FOR STEM CELL REPLACEMENT THERAPY IN THE US, EUROPE AND ASIA. A BARRIER TO REDUCING FBS USE IS THE LACK OF KNOWLEDGE ABOUT THE GF CONTENT OF FBS THAT IS CRITICAL FOR GROWTH OF THE RPE CELL PRODUCT. WE WILL MEASURE LEVELS OF FBS GFS THAT STIMULATE HUMAN RPE CELL PROLIFERATION. SELECTED RECOMBINANT HUMAN GFS WILL BE ENCAPSULATED IN CONTROLLED- RELEASE GF MICROBEADS THAT PROVIDE A STANDARDIZED GROWTH SIGNAL OVER TIME, TO REPLACE THE VARIABLE LEVELS OF BOVINE GFS PROVIDED BY FBS WITH DEFINED LEVELS OF NATIVE HUMAN RECOMBINANT GFS. THE GF MICROBEADS WILL BE ASSESSED IN A FACTORIAL DESIGN EXPERIMENT TO IDENTIFY MICROBEAD COMBINATIONS THAT SUPPORT RPE CELL GROWTH AT A REDUCED LEVEL OF FBS. THE MICROBEAD COMBINATION THAT SUPPORTS RPE CELL GROWTH WITHOUT FBS OR AT THE LOWEST LEVEL OF FBS WILL BE PACKAGED IN A DEFINED INSERT FOR SUSTAINABLE CULTURE (DISCTM) DEVICE TO SIMPLIFY RPE CELL MANUFACTURE. THE DISCTM WILL BE MANUFACTURED AS A COMMERCIAL PRODUCT MARKETED TO REDUCE FBS DEPENDENCE OF THE COMMERCIALLY IMPORTANT RPE CELLS. FUTURE WORK WILL APPLY THE MICROBEAD/DISCTM PLATFORM STRATEGY TO REDUCE FBS DEPENDENCE OF OTHER CELL TYPES. THE COMPANY STEMCULTURES (SCL) ROUTINELY MANUFACTURES MICROBEADS AND DISCSTM FOR SUSTAINED RELEASE OF GFS IN CULTURE MEDIA AND THE CO-LOCATED NEURAL STEM CELL INSTITUTE (NSCI) HAS EXTENSIVE RPE CELL CULTURE EXPERTISE. THE SCL-NSCI COLLABORATION SUCCESSFULLY COMPLETED PHASE 1 AIMS, IN PREPARATION TO MAKE PHASE 2 GOALS HIGHLY FEASIBLE.
Obligated Amount:
1729424.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2021-09-17
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
CONTROLLED-RELEASE MICROBEADS TO REPLACE GROWTH FACTORS IN FETAL BOVINE SERUM - PROJECT SUMMARY / ABSTRACT: FETAL BOVINE SERUM (FBS) CONTAINS A VARIETY GROWTH FACTORS (GFS) AND GF-STABILIZING AGENTS THAT HAVE A POTENT INFLUENCE ON CELL BEHAVIOR. LOT-TO-LOT VARIABILITY OF FBS, HOWEVER, RESULTS IN FLUCTUATION OF INITIAL GF LEVELS. THESE FLUCTUATIONS ARE FURTHER COMPLICATED BY TIME-DEPENDENT DECAY AT RATES UNIQUE TO EACH GF, RESULTING IN CHANGING GF RATIOS OVER TIME. THESE THREE FBS CHARACTERISTICS (VARIABLE INITIAL GF LEVELS, TIME-DEPENDENT DECAY, AND VARYING GF RATIOS OVER TIME) MAKE IT DIFFICULT TO KNOW ACTUAL GF LEVELS MAINTAINED DURING THE CULTURE PERIOD. KNOWLEDGE AND CONTROL OF GF LEVELS, HOWEVER, IS NEEDED TO SYSTEMATICALLY FORMULATE MEDIA TO EFFECTIVELY REPLACE THE GFS PROVIDED BY FBS WE PROPOSE TO MANUFACTURE CONTROLLED-RELEASE MICROSPHERES THAT MAINTAIN STABLE, DEFINED GF LEVELS TO FACILITATE THE DEVELOPMENT OF AN FBS-FREE MEDIUM. REPLACING FBS GFS IS A MEANINGFUL STEP TOWARD ADDRESSING THE FOA PA-18-816 GOALS OF: ‘BETTER DEFINING GROWTH MEDIUM TO IMPROVE REPRODUCIBILITY OF CELL CULTURE’ AND ‘SUPPORTING TECHNOLOGIES AND PRODUCTS TO EXPEDITE DEVELOPMENT OF BETTER SERUM SUBSTITUTES’. A CHALLENGE TO ORIGINATING SERUM-FREE PROTOCOLS IS THE RAPID DEGRADATION OF SOLUBLE GFS THAT ARE TYPICALLY ADDED TO MEDIA AT THE TIME OF USE. STEMCULTURES, LLC MANUFACTURES CONTROLLED-RELEASE POLY LACTIC-CO-GLYCOLIC ACID (PLGA) MICROBEADS THAT SLOWLY RELEASE GFS TO PRODUCE DEFINED AND STABLE GF LEVELS IN CULTURE MEDIA. THIS FLEXIBLE PLGA MICROBEAD PLATFORM WILL BE USED TO GENERATE A SERIES OF ‘CULTUREBEADS’ THAT RELEASE KEY FBS GFS TO MAINTAIN A STABLE MEDIA LEVEL OVER SEVERAL DAYS. FOUR FBS GFS WILL PROVIDE PROOF-OF-CONCEPT FOR THE CONTROLLED- RELEASE STRATEGY. THE INITIAL FOUR FBS GFS WERE SELECTED BASED ON: 1) PRESENCE IN FBS, 2) LABILITY AND 3) BIOACTIVITY. EACH CULTUREBEAD REPLACES ONE FBS GF, ALLOWING CULTUREBEADS TO BE COMBINED TO PROVIDE A STABLE GF MIXTURE. THE SECOND AIM ADVANCES AUTOMATED MICROFLUIDIC MANUFACTURING TO FACILITATE COST-EFFECTIVE CURRENT GOOD MANUFACTURING PROCESS (CGMP) COMPLIANT CULTUREBEADS PRODUCTION. THE INITIAL CULTUREBEADS TOOL KIT CAN BE UTILIZED FOR SPECIFIC CELL TYPES DEPENDENT ON THE SELECTED GFS, INCLUDING RETINAL PIGMENT EPITHELIUM (RPE) CELLS, CERTAIN MESENCHYMAL STEM CELLS AND PLURIPOTENT STEM CELLS WHERE THERE IS BROAD DEMAND. CULTUREBEADS MANUFACTURE OF RPE HAS IMMEDIATE APPLICATION FOR AN FDA-APPROVED, NIH-SPONSORED CLINICAL TRIAL. IN A FUTURE PHASE 2 STTR APPLICATION, THE CULTUREBEADS SERIES WILL BE EXPANDED USING MULTIPLEX ANALYSIS TO IDENTIFY ADDITIONAL FACTORS TO MORE COMPLETELY REPLACE FBS.
Obligated Amount:
225501.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2021-01-27
Link:
View on USAspending
Awarding Agency Name:
Small Business Administration
Transaction Description:
TO AID SMALL BUSINESSES IN MAINTAINING WORK FORCE DURING COVID-19 PANDEMIC.
Obligated Amount:
0.00
Face Value Of Loan:
50417.00
Total Face Value Of Loan:
50417.00

Paycheck Protection Program

Date Approved:
2021-01-27
Loan Status:
Paid in Full
SBA Guaranty Percentage:
100
Initial Approval Amount:
50417
Current Approval Amount:
50417
Race:
Unanswered
Ethnicity:
Unknown/NotStated
Gender:
Unanswered
Veteran:
Unanswered
Forgiveness Amount:
50810.67

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Related by address

553 CRESCENT AVENUE, SARATOGA SPRINGS, NY, United States, 12866

385 BWAY SARATOGA LLC SARATOGA STYLE, LLC NEWMAN 543, LLC

Date of last update: 26 Mar 2025

Sources: New York Secretary of State

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