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  5. NEOCHROMOSOME, INC.

NEOCHROMOSOME, INC.

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Company Details

Name: NEOCHROMOSOME, INC.
Jurisdiction: New York
Legal type: FOREIGN BUSINESS CORPORATION
Status: Active
Date of registration: 30 Apr 2021 (4 years ago)
Entity Number: 6002754
ZIP code: 11101
County: Queens
Place of Formation: Delaware
Address: 45-18 Court Sq W, Third Floor, LONG ISLAND CITY, NY, United States, 11101
Principal Address: 45-18 Court Sq W, Third Floor, Long Island City, NY, United States, 11101

Contact Details

Phone +1 410-585-4211

Chief Executive Officer

Name Role Address
LESLIE MITCHELL Chief Executive Officer 45-18 COURT SQ W, THIRD FLOOR, LONG ISLAND CITY, NY, United States, 11101

DOS Process Agent

Name Role Address
NEOCHROMOSOME, INC. DOS Process Agent 45-18 Court Sq W, Third Floor, LONG ISLAND CITY, NY, United States, 11101

Commercial and government entity program

CAGE number:
7C0N0
Status:
Obsolete
Type:
Non-Manufacturer
CAGE Update Date:
2025-03-10
SAM Expiration:
2026-03-06

Contact Information

POC:
LESLIE MITCHELL
Corporate URL:
www.neochromosome.com

Form 5500 Series

Employer Identification Number (EIN):
473354455
Plan Year:
2022
Number Of Participants:
0
Sponsors Telephone Number:
5083512902
File:
View File
Plan Year:
2022
Number Of Participants:
1
Sponsors Telephone Number:
4105854211
File:
View File
Plan Year:
2021
Number Of Participants:
3
Sponsors Telephone Number:
5083512902
File:
View File
Plan Year:
2021
Number Of Participants:
0
Sponsors Telephone Number:
6313947208
File:
View File
Plan Year:
2020
Number Of Participants:
0
Sponsors Telephone Number:
5083512902
File:
View File

History

Start date End date Type Value
2025-04-01 2025-04-01 Address 45-18 COURT SQ W, THIRD FLOOR, LONG ISLAND CITY, NY, 11101, USA (Type of address: Chief Executive Officer)
2024-10-04 2025-04-01 Address 45-18 COURT SQ W, THIRD FLOOR, LONG ISLAND CITY, NY, 11101, USA (Type of address: Chief Executive Officer)
2024-10-04 2025-04-01 Address 45-18 Court Sq W, Third Floor, LONG ISLAND CITY, NY, 11101, USA (Type of address: Service of Process)
2021-04-30 2024-10-04 Address 30-02 48TH AVENUE, LONG ISLAND CITY, NY, 11101, USA (Type of address: Service of Process)

Filings

Filing Number Date Filed Type Effective Date
250401030565 2025-04-01 BIENNIAL STATEMENT 2025-04-01
241004001079 2024-10-04 BIENNIAL STATEMENT 2024-10-04
210430000635 2021-04-30 APPLICATION OF AUTHORITY 2021-04-30

USAspending Awards / Financial Assistance

Date:
2021-06-02
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
SYNTHETIC NEO-AMPLICON PRODUCTION SYSTEM FOR HIGH CAPACITY THERAPEUTIC GENE DELIVERY - NEOCHROMOSOME, INC., CONFIDENTIAL PROJECT SUMMARY GENE THERAPY AIMS TO PROVIDE DURABLE CLINICAL BENEFIT WITH A SINGLE TREATMENT AND HAS POTENTIAL TO CURE A BROAD RANGE OF DISEASE CONDITIONS. VIRAL VECTOR-BASED GENE DELIVERY ACCOUNTS FOR THE MAJORITY OF CURRENT GENE THERAPY CLINICAL TRIALS. DESPITE ADVANCING THE FIELD, THESE VECTORS ARE LIMITED BY SMALL DNA PAYLOADS (5-10KB), DIFFICULT VECTOR PRODUCTION, TROPISM, IMMUNOGENICITY AND RISK OF CARCINOGENESIS. HERE WE PROPOSE TO DEVELOP A NEXT- GENERATION HERPES SIMPLEX VIRUS (HSV)-BASED VECTOR SYSTEM THAT OVERCOMES THESE LIMITATIONS. WE AIM TO LEVERAGE HSV AMPLICON VECTORS, WHICH CAN ENCODE UP TO ~150KB OF DESIGNER DNA SEQUENCE TOGETHER WITH HSV PACKAGING AND REPLICATION CIS-SIGNALS. THIS SIMPLE DESIGN, WHICH ELIMINATES ALL VIRAL PROTEIN-CODING GENES, ENSURES THESE VECTORS ARE NON-TOXIC. FURTHER, LIKE OTHER HSV VECTORS, AMPLICONS REMAIN EXTRACHROMOSOMAL ONCE INSIDE CELLS AND POSE NO RISK OF INSERTIONAL MUTAGENESIS. WHILE HSV AMPLICON GENE THERAPY VECTORS HAVE BEEN UNDER DEVELOPMENT FOR YEARS, THEIR USE HAS BEEN LIMITED BY SAFETY CONCERNS AND MANUFACTURING ISSUES. MORE SPECIFICALLY, THE ABSENCE OF ALL VIRAL GENES NECESSITATES THE USE OF HELPER VIRUS FOR AMPLICON PACKAGING; TO DATE AN AMPLICON PACKAGING SYSTEM THAT COMPLETELY EXCLUDES HELPER VIRUS CONTAMINATION HAS NOT BEEN ACHIEVED. HERE WE PROPOSE TO BUILD AN AMPLICON PACKAGING CELL LINE FOR RELIABLE PRODUCTION OF 100% PURE AMPLICON VECTOR POPULATIONS DEVOID OF HELPER GENE SEQUENCES. WE WILL DEMONSTRATE REPEATED PASSAGING OF AMPLICON VECTORS TO GENERATE HIGH TITER STOCKS WHILE MAINTAINING 100% PURITY. OUR VISION IS THAT LARGE PAYLOAD AMPLICON-MEDIATED GENE DELIVERY WILL ENABLE THE USE OF FULL-LENGTH HUMAN GENE LOCI INCLUDING INTRONS AND TRANSCRIPTIONAL REGULATORY SEQUENCES, ALLOWING FOR NATURAL SPATIAL AND TEMPORAL CONTROL OF THERAPEUTIC GENE EXPRESSION. HIGH CAPACITY VECTORS THAT CAN ACCOMMODATE LARGE AND MULTIGENE CASSETTES, SUCH AS HSV-1 DERIVED SYSTEMS, REPRESENT THE FUTURE OF GENE THERAPY TOOLS AND WILL BE ESSENTIAL TO THE TREATMENT OF COMPLEX GENETIC DISEASES PARTICULARLY IN THE BRAIN.
Obligated Amount:
323408.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2020-04-11
Link:
View on USAspending
Awarding Agency Name:
Small Business Administration
Transaction Description:
TO AID SMALL BUSINESSES IN MAINTAINING WORK FORCE DURING COVID-19 PANDEMIC.
Obligated Amount:
0.00
Face Value Of Loan:
23135.00
Total Face Value Of Loan:
0.00
Date:
2020-04-03
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
PLUG-AND-PLAY HLA FOR SAFER AND PERSONALIZED OFF-THE-SHELF CELL THERAPIES USING BIG-DNA TECHNOLOGY
Obligated Amount:
600000.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2019-07-26
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
YEAST SYNTHETIC BIOLOGY PLATFORM FOR PATHWAY-LEVEL ANTIMICROBIAL SCREENS
Obligated Amount:
150000.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00

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45-18 Court Sq W, Third Floor, Long Island City, NY, United States, 11101

OPENTRONS LABWORKS INC. REOPEN DIAGNOSTICS, LLC

Date of last update: 22 Mar 2025

Sources: New York Secretary of State

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