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COLD SPRING HARBOR LABORATORY

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Company Details

Name: COLD SPRING HARBOR LABORATORY
Jurisdiction: New York
Legal type: UNAUTHORIZED BUSINESS CORPORATION
Status: Inactive
Entity Number: 7557110

Contact Details

Phone +1 516-367-8800

Unique Entity ID

A UEI is a government-provided number, like a tax ID number, that’s used to identify businesses eligible for federal grants, awards and contracts.

Note: In April 2022, the federal government replaced its old identifier of choice, the Data Universal Numbering System (DUNS) number, with a government-issued UEI. Now all the federal government’s Integrated Award Environment systems use UEI numbers instead of DUNS numbers. So any entity doing business with the federal government must register for a UEI.

CAGE Code:
0DHK5
UEI Expiration Date:
2020-07-10

Business Information

Doing Business As:
CSH
Activation Date:
2019-07-11
Initial Registration Date:
2002-04-01

Commercial and government entity program

The The Commercial And Government Entity Code (CAGE) is assigned by the Department of Defense's Defense Logistics Agency (DLA) and represents your company's physical address for GSA's mailings, payments, and administrative records.

Note: A CAGE Code enables a company to contract with the U.S. government, allowing bid on government contracts and to receive government payments. Also for business this means that it's a Verified business entity and Has a validated physical address.

CAGE number:
0DHK5
Status:
Active
Type:
Non-Manufacturer
CAGE Update Date:
2025-03-18
CAGE Expiration:
2030-03-18
SAM Expiration:
2026-03-14

Contact Information

POC:
WALTER GOLDSCHMIDTS, PHD

Licenses

Number Type Date Last renew date End date Address Description
0349-22-117682 Alcohol sale 2024-02-27 2024-02-27 2026-02-28 1 BUNGTOWN ROAD, COLD SPRING HARBOR, New York, 11724 Club

USAspending Awards / Contracts

Procurement Instrument Identifier:
75N95B25P00067
Link:
View Award on USAspending website
Award Or Idv Flag:
AWARD
Award Type:
PURCHASE ORDER
Action Obligation:
10290.00
Base And Exercised Options Value:
10290.00
Base And All Options Value:
10290.00
Awarding Agency Name:
Department of Health and Human Services
Performance Start Date:
2025-06-12
Description:
TUITION PAYMENT FOR CSH LABORATORYS VISION: A PLATFORM FOR LINKING CIRCUITS, PERCEPTION & BEHAVIOR COURSE, HELD 6/12/25-6/28/25 - FOR 2 NIMH LAB EMPLOYEES
Naics Code:
541715: RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT NANOTECHNOLOGY AND BIOTECHNOLOGY)
Product Or Service Code:
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES
Procurement Instrument Identifier:
1333MF23PNFFM0137
Link:
View Award on USAspending website
Award Or Idv Flag:
AWARD
Award Type:
PURCHASE ORDER
Action Obligation:
10446.00
Base And Exercised Options Value:
10446.00
Base And All Options Value:
10446.00
Awarding Agency Name:
Department of Commerce
Performance Start Date:
2023-09-15
Description:
PCR AMPLIFY DNA EXTRACTS SEQUENCING SERVICES FOR NOAA/NMFS/NEFSC WOODS HOLE,MA.
Naics Code:
541990: ALL OTHER PROFESSIONAL, SCIENTIFIC, AND TECHNICAL SERVICES
Product Or Service Code:
F020: NATURAL RESOURCES/CONSERVATION- FISHERIES RESOURCES MANAGEMENT
Procurement Instrument Identifier:
1263VY19P0026
Link:
View Award on USAspending website
Award Or Idv Flag:
AWARD
Award Type:
PURCHASE ORDER
Action Obligation:
22590.00
Base And Exercised Options Value:
22590.00
Base And All Options Value:
22590.00
Awarding Agency Name:
Department of Agriculture
Performance Start Date:
2019-09-16
Description:
RNA QC CDNA PREP, LIBRARY PREP, PACBIO II RUN
Naics Code:
541715: RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, AND LIFE SCIENCES (EXCEPT NANOTECHNOLOGY AND BIOTECHNOLOGY)
Product Or Service Code:
AA21: R&D- AGRICULTURE: MARKETING (BASIC RESEARCH)

USAspending Awards / Financial Assistance

Date:
2025-05-16
Link:
View on USAspending
Awarding Agency Name:
National Science Foundation
Transaction Description:
REU SITE: CSHL NSF-REU BIOINFORMATICS AND COMPUTATIONAL NEUROSCIENCE SUMMER UNDERGRADUATE PROGRAM -THIS REU SITE AWARD TO COLD SPRING HARBOR LABORATORY (CSHL), LOCATED IN COLD SPRING HARBOR, NY, WILL SUPPORT THE TRAINING OF NINE STUDENTS FOR TEN WEEKS DURING THE SUMMERS OF 2025- 2027. THE REU BIOINFORMATICS AND COMPUTATIONAL NEUROSCIENCE PROGRAM TRAINS UNDERGRADUATE STUDENTS TO UTILIZE QUANTITATIVE TOOLS TO UNRAVEL BIOLOGICAL PROBLEMS. STUDENTS APPLY THEIR SKILLS BY PERFORMING HANDS-ON, HIGH-LEVEL RESEARCH THAT PREPARES THEM TO PURSUE AND EXCEL IN RESEARCH AND SCIENCE CAREERS. STUDENTS HAVE THE UNIQUE OPPORTUNITY TO LEARN AND BE TRAINED BY EXPERTS AT THE FOREFRONT OF THESE FIELDS. THIS LEVEL OF SPECIALIZED EXPERTISE MAY NOT BE AVAILABLE TO STUDENTS AT THEIR HOME INSTITUTIONS. STUDENTS WILL ALSO IMPROVE THEIR SCIENTIFIC COMMUNICATION SKILLS THROUGH SYMPOSIUM PRESENTATIONS AND NETWORKING WITH SCIENTISTS. THE REU PROGRAM AT CSHL HAS A COMPELLING RECORD OF RECRUITING AND DEVELOPING STUDENTS WHO PURSUE ADVANCED DEGREES AND ENTER SUCCESSFUL CAREERS IN BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, COMPUTATIONAL NEUROSCIENCE, OR RELATED SCIENTIFIC AREAS. ASSESSMENT OF THIS PROGRAM WILL BE DONE THROUGH A SERIES OF SURVEYS. STUDENTS SHOULD APPLY TO THE REU SITE USING NSF ETAP (EDUCATION AND TRAINING APPLICATION: HTTPS://ETAP.NSF.GOV). THE OBJECTIVE OF THE CSHL REU IN BIOINFORMATICS AND COMPUTATIONAL NEUROSCIENCE IS TO PROVIDE UNDERGRADUATE STUDENTS WITH THE TRAINING AND SKILLS NECESSARY TO NAVIGATE THE DIGITAL LANDSCAPE OF MODERN SCIENCE RESEARCH THROUGH A WELL-ROUNDED, COMPREHENSIVE PROGRAM. DURING THE PROGRAM, STUDENTS WORK ON A RESEARCH PROJECT WHILE BEING MENTORED BY A CSHL FACULTY MEMBER. THEY ALSO ATTEND LECTURES AND WORKSHOPS RANGING FROM BIOLOGY AND QUANTITATIVE TECHNIQUES TO RESEARCH ETHICS, SCIENCE COMMUNICATION, CAREERS IN SCIENCE, AND PREPARATIONS FOR GRADUATE SCHOOL. THESE LECTURES ARE PRESENTED BY CSHL?S EXPERT FACULTY AND STAFF. AT THE END OF THEIR PROGRAM, STUDENTS PREPARE AND PRESENT THEIR WORK IN A RESEARCH SYMPOSIUM OPEN TO THE ENTIRE CSHL COMMUNITY AND WRITE A SCIENTIFIC REPORT. A CONTINUING MENTOR/MENTEE RELATIONSHIP IS FOSTERED THROUGHOUT AND BEYOND THE PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Obligated Amount:
421425.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2025-05-15
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
CSHL CELL & DEVELOPMENTAL BIOLOGY OF XENOPUS COURSE (2025-2029) - ABSTRACT IN VIVO ANIMAL MODELS ARE AN IMPORTANT TOOL FOR THE UNDERSTANDING OF HUMAN DEVELOPMENT AND DISEASE. STUDIES USING THE FROG XENOPUS HAVE MADE SIGNIFICANT CONTRIBUTIONS TO OUR UNDERSTANDING OF FUNDAMENTAL PROCESSES SUCH AS CELL CYCLE REGULATION, TRANSCRIPTION, TRANSLATION AND MANY OTHER TOPICS. XENOPUS IS REMARKABLE FOR STUDYING DEVELOPMENT AND DISEASE, INCLUDING BIRTH DEFECTS, CANCER, AND STEM CELL BIOLOGY. BECAUSE XENOPUS ARE EASY TO RAISE, PRODUCING MANY THOUSANDS OF EGGS PER DAY, THESE FROGS HAVE EMERGED AS A PREMIERE MODEL FOR UNDERSTANDING OF HUMAN BIOLOGY FROM THE FUNDAMENTAL BUILDING BLOCKS TO THE WHOLE ORGANISM. THE COLD SPRING HARBOR LABORATORY COURSE ON CELL & DEVELOPMENTAL BIOLOGY OF XENOPUS: GENE DISCOVERY & DISEASE PROVIDES EXTENSIVE LABORATORY EXPOSURE TO THE BIOLOGY AND MANIPULATION OF EMBRYOS FROM THE FROGS XENOPUS LAEVIS AND XENOPUS TROPICALIS. THE COURSE PREPARES STUDENTS FOR INDEPENDENT RESEARCH IN THE CELL, GENETIC, AND MOLECULAR ANALYSIS OF VERTEBRATE DEVELOPMENT. IT INTRODUCES THE UNIQUE ATTRIBUTES OF XENOPUS WHICH ALLOW THE FUNCTIONAL ANALYSIS OF DEVELOPMENTALLY IMPORTANT GENES, WHILST AT THE SAME TIME INTRODUCING THE MAJOR TECHNOLOGIES OF MODERN MOLECULAR AND CELLULAR DEVELOPMENTAL BIOLOGY, IN A SYSTEM THAT ALLOWS DIRECT MANIPULATION OF EMBRYOS AND VISUALIZATION OF DEVELOPMENTAL PROCESSES. AT THE END OF THE COURSE, STUDENTS ARE READY TO EMBARK ON CUTTING EDGE RESEARCH USING THIS POWERFUL MODEL OF HUMAN DEVELOPMENT. THE XENOPUS COURSE IS DESIGNED TO TRAIN STUDENTS HOW TO TAKE ADVANTAGE OF THESE UNIQUE QUALITIES. IT IS OFTEN DIFFICULT FOR INVESTIGATORS TO INITIATE STUDIES OF XENOPUS DEVELOPMENT ON THEIR OWN BECAUSE THE TECHNIQUES FOR RAISING EMBRYOS OR MANIPULATING THEM ARE UNFAMILIAR OR BECAUSE THEIR BACKGROUND KNOWLEDGE OF DEVELOPMENTAL BIOLOGY IS INADEQUATE. THIS COURSE IS DESIGNED TO PROVIDE STUDENTS WITH A CONCENTRATED AND REPEATED EXPOSURE TO THE MOST IMPORTANT RESEARCH TECHNIQUES, AND THE RESEARCHERS DOING THEM, SO THAT THEY INITIATE THEIR OWN INDEPENDENT RESEARCH PROJECTS AFTER RETURNING TO THEIR HOME INSTITUTIONS. THE COURSE PROVIDES AN INTENSIVE EXPOSURE, OVER A TWO-WEEK PERIOD, TO THE BIOLOGY AND MANIPULATION OF XENOPUS EMBRYOS. THE COURSE ALSO PROVIDES A RESOURCE NETWORK THAT THE STUDENTS CAN EASILY ACCESS AFTER THEY HAVE RETURNED TO THEIR HOME LABORATORIES. THROUGH THESE ROUTES, THE COURSE TRAINS INVESTIGATORS AT THE ADVANCED GRADUATE, POSTDOCTORAL AND FACULTY LEVELS TO USE XENOPUS IN THEIR RESEARCH DURING THE COURSE, THE STUDENTS ANALYZE ANY PHENOTYPES GENERATED FROM CRISPR/CAS9 BASED GENE DEPLETION WHILE LEARNING THE DIVERSE ARRAY OF TECHNIQUES AVAILABLE IN XENOPUS. IN PREVIOUS COURSES, WE HAVE GUIDED STUDENTS IN THE ABLATION OF A WIDE VARIETY OF GENES AND HELPED THEM DESIGN SUITABLE ASSAYS FOR THEIR BIOLOGICAL INTERESTS. MOST RECENTLY, STUDENTS HAVE TARGETED AUTISM GENES, THYROID GENES AND IMMUNE MODULATORS, SEVERAL OF WHICH HAVE ALREADY LED TO PUBLICATIONS. APPROACHES COVERED WILL INCLUDE MICROINJECTION AND MOLECULAR MANIPULATIONS SUCH AS CRISPR/CAS9 KNOCKOUTS, ANTISENSE MORPHOLINO-BASED DEPLETIONS, TRANSGENICS, AND MRNA OVEREXPRESSION. IN ADDITION, STUDENTS CAN COMBINE THESE TECHNIQUES WITH EXPLANT AND TRANSPLANT METHODS TO SIMPLIFY OR TEST TISSUE LEVEL INTERACTIONS. ADDITIONAL METHODS INCLUDE MRNA IN SITU HYBRIDIZATION, HYBRIDIZATION CHAIN REACTION (HCR), AND PROTEIN IMMUNOHISTOCHEMISTRY AS WELL AS BASIC BIOINFORMATIC TECHNIQUES FOR GENE COMPARISON AND FUNCTIONAL ANALYSIS. GENOMIC AND SYSTEMS BIOLOGY APPROACHES WILL BE INTRODUCED, INCLUDING SINGLE-CELL TECHNOLOGY. BIOCHEMICAL APPROACHES SUCH AS PROTEOMICS AND MASS SPECTROMETRY AND BIOMECHANICAL CONCEPTS WILL ALSO BE DISCUSSED. FINALLY, TO VISUALIZE SUBCELLULAR AND INTERCELLULAR ACTIVITIES, WE WILL INTRODUCE A VARIETY OF SAMPLE PREPARATION AND IMAGING METHODS INCLUDING TIME-LAPSE, FLUORESCENT IMAGING, OPTICAL COHERENCE TOMOGRAPHY AND CONFOCAL MICROSCOPY. IT IS ANTICIPATED THAT THE BASIC ORGANIZATION OF THE COURSE AND SOME
Obligated Amount:
1074626.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2025-05-12
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
CSHL 2025 MECHANISMS OF METABOLIC SIGNALING CONFERENCE - COLD SPRING HARBOR LABORATORY CONFERENCE ON MECHANISMS OF METABOLIC SIGNALING MAY 13-17, 2025 PROJECT SUMMARY THIS PROPOSAL SEEKS SUPPORT FOR THE MEETING ON “MECHANISMS OF METABOLIC SIGNALING” TO BE HELD AT COLD SPRING HARBOR LABORATORY IN MAY 13 - 17, 2025. THE MEETING WILL ASSEMBLE LEADERS IN THE FIELD, TOGETHER WITH JUNIOR FACULTY, POSTDOCTORAL FELLOWS AND GRADUATE STUDENTS, TO DISCUSS THE LATEST ADVANCES IN OUR UNDERSTANDING OF METABOLIC REGULATION AND ITS ROLE IN NORMAL PHYSIOLOGY AS WELL AS A VARIETY OF DISEASE STATES RANGING FROM OBESITY TO CANCER. METABOLIC PROCESSES ARE REQUIRED FOR LIFE, AND ARE REMARKABLY SIMILAR FROM ORGANISM TO ORGANISM AND FROM CELL TO CELL. IN MAMMALS, SPECIFIC CELL TYPES USE METABOLIC PATHWAYS IN HIGHLY SPECIALIZED WAYS TO CONDUCT THEIR CELL-SPECIFIC FUNCTIONS. FURTHER, THE SPECIALIZED FUNCTION OF SOME CELL TYPES SERVES TO MAINTAIN METABOLIC HOMEOSTASIS OF THE MULTICELLULAR ORGANISM BY REGULATING LEVELS OF HORMONE AND METABOLITE MESSENGERS IN THE BLOODSTREAM. METABOLIC DISEASES SUCH AS OBESITY AND DIABETES RESULT WHEN THOSE PROCESSES FAIL. AT THE SAME TIME, CANCER IS INCREASINGLY RECOGNIZED AS A STATE WHEREBY THE MALIGNANT CELL PROLIFERATES BY ALTERING ITS FUEL METABOLISM AND IGNORING METABOLIC SIGNALS. THE MEETING WILL COVER A BROAD SPECTRUM OF TOPICS RANGING FROM METABOLIC CROSSTALK WITH GENOME AND EPIGENOME TO INTERORGAN CROSSTALK AND NUTRIENT UTILIZATION. IN ADDITION, ONE SESSION IS DEDICATED TO EMERGING TECHNOLOGIES IN THE FIELD. EACH SESSION WILL BE CHAIRED BY A LEADING SCIENTIST IN THE FIELD. ORAL PRESENTATIONS WILL BE GIVEN BY A GROUP OF DISTINGUISHED INVITED SPEAKERS AS WELL AS SPEAKERS SELECTED FROM SUBMITTED ABSTRACTS. SELECTED SPEAKERS WILL INCLUDE GRADUATE STUDENTS, POSTDOCTORAL FELLOWS AND JUNIOR FACULTY AIMING FOR MAXIMAL INCLUSION OF YOUNG INVESTIGATORS. OF SPECIAL IMPORTANCE ARE THE TWO POSTER SESSIONS, WHERE MANY PARTICIPANTS CAN PRESENT THEIR WORK IN AN ATMOSPHERE CONDUCIVE TO INFORMAL DISCUSSION. THE MEETING WILL BE OF MODERATE SIZE, AND WE EXPECT ABOUT 250 PEOPLE TO ATTEND, THE VAST MAJORITY OF WHOM WILL BE PRESENTING A POSTER OR TALK. SESSION CHAIRS AND PRESENTERS WILL BE REQUIRED TO ATTEND IN-PERSON TO ENSURE A CRITICAL MASS OF ATTENDEES GATHERING AT COLD SPRING HARBOR; HOWEVER, WE WILL FACILITATE AN ADDITIONAL VIRTUAL AUDIENCE LAYERED ON TOP OF THE IN-PERSON ATTENDANCE. WE TOOK THIS APPROACH SUCCESSFULLY AT THE 2023 MEETING. THIS WILL BE IMPORTANT BECAUSE VIRTUAL ATTENDANCE AT MEETINGS WILL HELP TO REDUCE THE EFFECTS OF SCIENTIFIC CONFERENCES ON CLIMATE CHANGE AND ENABLE MORE EQUITABLE PARTICIPATION FROM LABS AROUND THE WORLD.
Obligated Amount:
25000.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2025-05-19
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
MECHANISM BY WHICH KETOGENIC DIET UNCOUPLES TUMOR GROWTH AND OVERALL SURVIVAL - THE OVERARCHING GOAL OF THIS PROPOSAL IS TO ADD TO THE UNDERSTANDING OF THE COMPLEX INTERACTION BETWEEN THE TUMOR AND THE HOST ORGANISM TO FACILITATE NEW THERAPEUTIC APPROACHES IN CANCER MEDICINE. SPECIFICALLY, WE AIM TO ESTABLISH THE MECHANISTIC EXPLANATION FOR THE OBSERVATION IN TWO IL-6 ASSOCIATED MURINE MODELS OF CANCER CACHEXIA THAT KD DELAYS TUMOR GROWTH BUT ACCELERATES CANCER CACHEXIA AND SHORTENS SURVIVAL. WE DISCOVERED THAT THIS UNCOUPLING MAY BE A CONSEQUENCE OF THE BIOCHEMICAL INTERACTION OF TWO SIMULTANEOUSLY OCCURRING NADPH-DEPENDENT PATHWAYS. WITHIN THE TUMOR, INCREASED PRODUCTION OF LPPS AND, CONSEQUENTLY, SATURATION OF THE GLUTATHIONE SYSTEM LEADS TO FERROPTOTIC DEATH OF CANCER CELLS. SYSTEMICALLY, REDOX IMBALANCE AND NADPH DEPLETION IMPAIRS THE BIOSYNTHESIS OF CORTICOSTERONE, THE MAIN REGULATOR OF METABOLIC STRESS, IN THE ADRENAL GLANDS. THE PROPOSAL SEEKS TO BUILD ON THESE DISCOVERIES IN THREE WAYS. FIRST, WE WILL DETERMINE SPECIFIC POLYUNSATURATED FAT ENRICHED DIETS AND FERROPTOSIS INDUCING DRUGS, INCLUDING LICENSED MEDICATIONS, THAT EXACERBATE THE ANTI-CANCER EFFECT. SECOND, AFTER VALIDATING THAT GLUCOCORTICOID DEFICIENCY IS A CRITICAL COMPONENT OF SURVIVAL REDUCTION OF THE HOST ORGANISM, USING PLASMA, LIVER, AND ADRENAL FOCUSED ASSAYS, WE WILL USE SYSTEMATIC PHARMACOLOGICAL RESCUE EXPERIMENTS TO ENABLE A THERAPEUTIC WINDOW FOR KD INTERVENTION. THIRD, WE WILL TRACK HOW OXIDATIVE STRESS INDUCED GDF-15 ELEVATIONS MAY CONSPIRE WITH IL-6 ELEVATIONS TO DRIVE CACHEXIA ASSOCIATED ANOREXIA VIA NEURONAL CIRCUITS AND THEREBY CAUSE THE NEGATIVE ENERGY BALANCE THAT ACCELERATES CACHEXIA ONSET IN KD FED MICE. THE RESULTS OF THIS RESEARCH MAY BE OF INTEREST TO SCIENTISTS AND MEDICAL PROFESSIONALS. A COMBINATION OF ADMINISTRATION OF SYNTHETIC GCS MAY IMPROVE FOOD INTAKE, NORMALIZES GLUCOSE HOMEOSTASIS AND UTILIZATION OF NUTRITIONAL SUBSTANCES, DELAY THE ONSET OF CANCER CACHEXIA AND EXTENDS SURVIVAL OF TUMOR-BEARING MICE FED KD, WHILE NOT COUNTERACTING THE REDUCED TUMOR GROWTH INDUCED BY THE KD-INDUCED FERROPTOSIS. THESE STUDIES WILL EMPHASIZE THE IMPORTANCE OF CONSIDERING THE IMPACT OF CANCER TREATMENTS ON THE HOST AND THE TUMOR.
Obligated Amount:
1062713.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00
Date:
2025-04-15
Link:
View on USAspending
Awarding Agency Name:
Department of Health and Human Services
Transaction Description:
BIOLOGY AND VULNERABILITIES OF POU2F3+ TUFT CELL-LIKE CARCINOMAS - PROJECT SUMMARY HUMAN CANCERS CAN BE CLASSIFIED ACCORDING TO THEIR CELLULAR LINEAGE, WHICH IS OFTEN DEFINED BY THE PRESENCE OF MASTER REGULATOR TRANSCRIPTION FACTORS. IN SEVERAL CLINICAL CONTEXTS, OPPORTUNITIES EXIST TO TARGET MASTER REGULATORS AS A THERAPEUTIC STRATEGY (E.G. ANTAGONISTS OF THE ANDROGEN RECEPTOR OR DEGRADERS OF IKAROS/AIOLOS). HOWEVER, SCENARIOS ALSO EXIST IN WHICH THE ABERRANT EXPRESSION OF A MASTER REGULATOR CAN PROMOTE LINEAGE PLASTICITY, WHICH CAN ALLOW TUMOR CELLS TO EVADE TARGETED THERAPIES. THESE CLINICAL OBSERVATIONS HIGHLIGHT THE IMPORTANCE OF INVESTIGATING THE BIOLOGY AND MECHANISMS OF LINEAGE MASTER REGULATORS IN ONCOLOGY. OUR LAB RECENTLY REPORTED THE EXISTENCE OF A TUFT CELL-LIKE LINEAGE OF HUMAN CARCINOMA, WHICH IS A TUMOR DEFINED BY THE EXPRESSION OF POU2F3. WE DESCRIBED TUFT CELL-LIKE CARCINOMAS AS A NON-NEUROENDOCRINE FORM OF SMALL CELL LUNG CANCER (SCLC), HOWEVER SUBSEQUENT STUDIES HAVE SHOWN THAT POU2F3+ CARCINOMAS EXIST IN SEVERAL OTHER ORGANS AS WELL. IN THIS RESEARCH PROPOSAL, WE SEEK TO DEFINE THE UNIQUE BIOLOGY AND MOLECULAR MECHANISMS THAT DISTINGUISH POU2F3+ CARCINOMAS FROM OTHER FORMS OF HUMAN CANCER, WITH A LONG-TERM OBJECTIVE OF ADVANCING THERAPEUTIC SOLUTIONS FOR THIS NEWLY IDENTIFIED TUMOR LINEAGE. THE FIRST AIM OF THIS PROJECT WILL FOCUS ON REVEALING MOLECULAR MECHANISMS, BUILDING UPON OUR RECENT DISCOVERY OF OCA-T1/OCA-T2 AS OBLIGATE COACTIVATORS OF POU2F3 IN THE TUFT CELL LINEAGE. FOR THIS WORK, WE WILL EMPLOY OUR LATEST INNOVATIONS IN GENOME EDITING TECHNOLOGY AND EPIGENOMICS TO DEFINE THE EFFECTORS OF THE POU2F3/OCA-T COMPLEX IN POU2F3+ SCLC. THESE EFFORTS WILL HAVE POTENTIAL TO REVEAL BIOCHEMICAL OPPORTUNITIES THAT ALLOW FOR PHARMACOLOGICAL MODULATION OF POU2F3 IN CANCER. THE SECOND AIM WILL EVALUATE THE UNIQUE BIOLOGICAL PROPERTIES OF NEOPLASTIC TUFT CELLS IN VIVO, WHICH BUILDS UPON OUR PRELIMINARY DATA SHOWING THAT ENGINEERING OF CANCER GENE MUTATIONS INTO PULMONARY TUFT CELLS LEADS TO THE GENERATION OF SCLC- LIKE TUMORS THAT EXPRESS POU2F3. THESE UNIQUE GENETIC MODELS WILL ALLOW US TO EXPLORE BIOLOGICAL QUESTIONS THAT WOULD OTHERWISE BE IMPOSSIBLE USING HUMAN CANCER CELL LINES. SPECIFICALLY, WE WILL INVESTIGATE A) WHICH SPECIFIC TUMOR GENOTYPES ARE PERMISSIVE FOR FORMING TUFT CELL CARCINOMAS B) WHICH TUMOR GENOTYPES DRIVE LINEAGE PLASTICITY IN THIS CONTEXT, PARTICULARLY TRANSITIONS BETWEEN TUFT AND NEUROENDOCRINE FATES AND C) HOW CYTOTOXIC CHEMOTHERAPY SELECTS FOR SPECIFIC CELLULAR STATES IN THE SETTING OF A TUFT CELL CARCINOMA. THE THIRD AIM OF THIS PROPOSAL SEEKS TO UNDERSTAND TUFT CELL IDENTITY AS AN ACQUIRED STATE AND AS A DRUG RESISTANCE MECHANISM IN PROSTATE ADENOCARCINOMA. WE HAVE DEVELOPED METHODS FOR REPROGRAMMING CARCINOMAS INTO A TUFT CELL STATE USING POU2F3/OCA-T CO-EXPRESSION, WHICH WE WILL INCORPORATE INTO THE RAPIDCAP MODEL OF PROSTATE CANCER TO STUDY ITS IMPACT ON DISEASE PROGRESSION AND CASTRATION RESISTANCE. COLLECTIVELY, THE RESEARCH OUTLINED IN THIS PROPOSAL WILL ADVANCE OUR FUNDAMENTAL UNDERSTANDING OF THE BIOLOGY AND THERAPEUTIC VULNERABILITIES OF POU2F3+ HUMAN CARCINOMAS.
Obligated Amount:
1274315.00
Face Value Of Loan:
0.00
Total Face Value Of Loan:
0.00

Trademarks Section

Serial Number:
99202176
Mark:
SCIENCE MAKES LIFE BETTER
Status:
NEW APPLICATION - RECORD INITIALIZED NOT ASSIGNED TO EXAMINER
Mark Type:
TRADEMARK, SERVICE MARK
Application Filing Date:
2025-05-26
Mark Drawing Type:
Standard character mark
Mark Literal Elements:
SCIENCE MAKES LIFE BETTER
USPTO Link:
View Trademark Status and Document Retrieval (TSDR)

Goods And Services

For:
Organization of conferences and symposia for the discussion, dissemination and exchange of scientific data and ideas on topics of interest to the scientific community; development and dissemination of educational materials of others in the fields of biology, molecular biology, genetics, genomics, DN...
International Classes:
041 - Primary Class
Class Status:
Active
For:
Downloadable journals, magazines, and periodicals
International Classes:
009 - Primary Class
Class Status:
Active
For:
Scientific books, textbooks, manuals, magazines, journals and periodicals
International Classes:
016 - Primary Class
Class Status:
Active
For:
licensing of intellectual property in the fields of biology, chemistry, medicine, bioinformatics, computer software and hardware and computational technologies; intellectual property consultation; conducting scientific and laboratory research in the fields of biology, molecular biology, medicine, ge...
International Classes:
042 - Primary Class
Class Status:
Active
Serial Number:
87574322
Mark:
BASE PAIRS
Status:
SECTION 8 & 15-ACCEPTED AND ACKNOWLEDGED
Mark Type:
SERVICE MARK
Application Filing Date:
2017-08-18
Mark Drawing Type:
Illustration: Drawing or design which also includes word(s)/letter(s)/number(s)
Mark Literal Elements:
BASE PAIRS
USPTO Link:
View Trademark Status and Document Retrieval (TSDR)

Goods And Services

For:
Educational services, namely, providing podcasts in the field of genetic testing and research
First Use:
2016-06-15
International Classes:
041 - Primary Class
Class Status:
Active
Serial Number:
87571657
Mark:
BASE PAIRS
Status:
SECTION 8 & 15-ACCEPTED AND ACKNOWLEDGED
Mark Type:
SERVICE MARK
Application Filing Date:
2017-08-16
Mark Drawing Type:
Standard character mark
Mark Literal Elements:
BASE PAIRS
USPTO Link:
View Trademark Status and Document Retrieval (TSDR)

Goods And Services

For:
Educational services, namely, providing podcasts in the field of genetic testing and research
First Use:
2016-06-15
International Classes:
041 - Primary Class
Class Status:
Active
Serial Number:
87022973
Mark:
BIORXIV
Status:
SECTION 8 & 15-ACCEPTED AND ACKNOWLEDGED
Mark Type:
SERVICE MARK
Application Filing Date:
2016-05-03
Mark Drawing Type:
Standard character mark
Mark Literal Elements:
BIORXIV
USPTO Link:
View Trademark Status and Document Retrieval (TSDR)

Goods And Services

For:
Providing a website featuring technology enabling users to post, access, share, comment on, and submit unpublished preprints of manuscripts in the field of life sciences; Electronic storage services for archiving of unpublished preprints of manuscripts in the field of life sciences
First Use:
2013-11-11
International Classes:
042 - Primary Class
Class Status:
Active
Serial Number:
78967176
Mark:
GENES & DEVELOPMENT
Status:
REGISTERED AND RENEWED
Mark Type:
TRADEMARK
Application Filing Date:
2006-09-05
Mark Drawing Type:
Illustration: Drawing or design which also includes word(s)/letter(s)/number(s)
Mark Literal Elements:
GENES & DEVELOPMENT
USPTO Link:
View Trademark Status and Document Retrieval (TSDR)

Goods And Services

For:
Scientific Journals
First Use:
1997-01-01
International Classes:
016 - Primary Class
Class Status:
Active

Tax Exempt

Employer Identification Number (EIN) :
11-2013303
Classification:
Educational Organization, Scientific Organization, Local Association of Employees, Horticultural Organization, Business League, Voluntary Employees' Beneficiary Association (Govt. Emps.), Mutual Ditch or Irrigation Co., Cemetery Company, Other Mutual Corp. or Assoc.
Ruling Date:
1964-08
Deductibility:
Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)

Motor Carrier Census

Carrier Operation:
Intrastate Hazmat
Phone:
(516) 367-8339
Fax:
(516) 367-6873
Add Date:
2009-10-08
Operation Classification:
Private(Property)
power Units:
13
Drivers:
8
Inspections:
0
FMCSA Link:
View on FMCSA website

Court Cases

Court Case Summary

Filing Date:
2010-02-16
Status:
Terminated
Nature Of Judgment:
no monetary award
Jury Demand:
Neither plaintiff nor defendant demands jury
Nature Of Suit:
Patent

Parties

Party Name:
COLD SPRING HARBOR LABORATORY
Party Role:
Plaintiff
Party Name:
COLD SPRING HARBOR LABORATORY
Party Role:
Plaintiff
Party Name:
ROPES & GRAY LLP
Party Role:
Defendant

Court Case Summary

Filing Date:
2009-08-11
Status:
Terminated
Nature Of Judgment:
no monetary award
Jury Demand:
Plaintiff demands jury
Nature Of Suit:
Trademark

Parties

Party Name:
COLD SPRING HARBOR LABORATORY
Party Role:
Plaintiff
Party Name:
COLD SPRING PUBLISHING, LLC
Party Role:
Defendant

Court Case Summary

Filing Date:
2003-08-18
Status:
Terminated
Nature Of Judgment:
Missing
Jury Demand:
Missing
Nature Of Suit:
Patent

Parties

Party Name:
COLD SPRING HARBOR LABORATORY
Party Role:
Plaintiff
Party Name:
INVITROGEN CORPORATION
Party Role:
Defendant
Party Name:
COLD SPRING HARBOR LABORATORY
Party Role:
Plaintiff

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Date of last update: 19 Mar 2025

Sources: New York Secretary of State

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