RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.

TYVNMW8FNQQ3

47X98

2025-07-19

http://corporate.rfmh.org/

NEW YORK STATE PSYCHIATRIC INSTITUTE

2024-07-22

2005-11-22

47WK1

Active

Non-Manufacturer

2024-07-22

2029-07-22

2025-07-18

ROBERT BURKE

http://corporate.rfmh.org

141410842

2023

1865

5184744661

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2022

1857

5184745661

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2021

1773

5184745661

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2020

1714

5184745661

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2019

1674

5184745661

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36C24222N0696

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AWARD

DELIVERY ORDER

-10250.00

-10250.00

-10250.00

Department of Veterans Affairs

2022-09-28

REMOVE FUNDING- SERVICES BEING PROVIDED THROUGH OTHER METHOD. STUDIES INVOLVING QUALITATIVE ANALYSIS OF INDIVIDUAL SUICIDE SAFETY INTERVENTION DELIVERED VIA TELEHEALTH-GUIDE DEVELOPMENT, CONSULTATION, TRAINING, REPORT DEVELOPMENT PER YEAR

541720: RESEARCH AND DEVELOPMENT IN THE SOCIAL SCIENCES AND HUMANITIES

AN42: HEALTH R&D SERVICES; HEALTH CARE - OTHER; APPLIED RESEARCH

36C24222D0017

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IDV

0.00

-27000.00

Department of Veterans Affairs

2021-11-23

TERMINATE FOR CONVENIENCE- STUDIES INVOLVING QUALITATIVE ANALYSIS OF INDIVIDUAL SUICIDE SAFETY INTERVENTION DELIVERED VIA TELEHEALTH- GUIDE DEVELOPMENT, CONSULTATION, TRAINING, REPORT DEVELOPMENT PER YEAR

541720: RESEARCH AND DEVELOPMENT IN THE SOCIAL SCIENCES AND HUMANITIES

AN42: HEALTH R&D SERVICES; HEALTH CARE - OTHER; APPLIED RESEARCH

36C24222N0255

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AWARD

DELIVERY ORDER

9000.00

9000.00

9000.00

Department of Veterans Affairs

2021-11-23

TASK ORDER- STUDIES INVOLVING QUALITATIVE ANALYSIS OF INDIVIDUAL SUICIDE SAFETY INTERVENTION DELIVERED VIA TELEHEALTH- ESTIMATED 60 HOURS OF GUIDE DEVELOPMENT, CONSULTATION, TRAINING, REPORT DEVELOPMENT PER YEAR

541720: RESEARCH AND DEVELOPMENT IN THE SOCIAL SCIENCES AND HUMANITIES

AN42: HEALTH R&D SERVICES; HEALTH CARE - OTHER; APPLIED RESEARCH

2025-03-31

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Department of Health and Human Services

RECAST BUFFALO - THE NYS OFFICE OF MENTAL HEALTH (OMH) RECAST BUFFALO PROGRAM'S POPULATION OF FOCUS IS BLACK AFRICAN AMERICANS RESIDING IN OR ATTENDING SCHOOL IN FIVE BUFFALO EAST SIDE NEIGHBORHOODS, WITH A SPECIAL FOCUS ON HIGH-RISK YOUTH AND THEIR FAMILIES. THESE NEIGHBORHOODS ARE HIGHLY IMPACTED BY THE RACIALLY MOTIVATED MASS SHOOTING THAT OCCURRED ON MAY 14, 2022. BLACK/AFRICAN AMERICAN YOUTH IN THESE NEIGHBORHOODS EXPERIENCE MULTIPLE RISK FACTORS INCLUDING THE IMPACTS OF STRUCTURAL RACISM, THE COVID PANDEMIC AND SCHOOL DISRUPTION, AND THE TRAUMA OF THE BUFFALO AND UVALDE SHOOTINGS WITH IN 10 DAYS. IN THESE NEIGHBORHOODS, YOUTH AND FAMILIES EXPERIENCE POWERLESSNESS AND SIGNIFICANT BARRIERS TO ACCESSING HIGH-QUALITY EDUCATION AND HOUSING, ADEQUATE HEALTH AND MENTAL HEALTH CARE, AND GOOD JOBS WITH FAIR PAY. CURRENT RESOURCES NEEDS AND GAPS AND CHALLENGES ASSOCIATED WITH ACCESS TO OR QUALITY OF SERVICES IN THESE COMMUNITIES ARE LONG-TERM AND COMPOUNDED BY THE MASS SHOOTING. THE NYS OMH SERG PROGRAM FOR BUFFALO HAS CATALYZED A ONE-YEAR PROCESS OF COMMUNITY PLANNING AND HEALING, WHICH WILL BE SUSTAINED BY RECAST. NYS OMH'S RECAST PROGRAM WILL INCLUDE A COALITION OF DIVERSE COMMUNITY STAKEHOLDERS TO ENSURE THAT COMMUNITY VOICE AND PARTNERSHIP IS INVOLVED IN ALL ASPECTS OF THE GRANT PROJECT, WHICH WILL SUPPORT RECOVERY-ORIENTED, TRAUMA-INFORMED, AND EQUITY-BASED BEHAVIORAL HEALTH AND WELLNESS. THE PROPOSED PROGRAM INCLUDES THREE RECAST FUNDED TRAUMA-INFORMED BEHAVIORAL HEALTH SERVICES:1) A BLACK MENTAL HEALTH RESPONSE TEAM LED BY BESTSELF BEHAVIORAL HEALTH WILL CONTINUE OUTREACH AND ENHANCEMENT WITH YOUTH AND FAMILIES IN THE EAST SIDE; 2) UNIVERSITY PSYCHIATRIC PRACTICE, IN COLLABORATION WITH SAYYES BUFFALO AND THE BUFFALO PUBLIC SCHOOLS, WILL PROVIDE CLINICAL SUPPORTS FOR STUDENTS STRUGGLING WITH COMMUNITY TRAUMA AND TRAINING FOR EDUCATORS; AND 3) BUFFALO COMMUNITY NON-TRADITIONAL MENTAL WELLNESS PROGRAMS WILL CONTINUE A FOCUS ON RESPECTING AND INTEGRATING BLACK/AFRICAN AMERICAN TRADITIONS AND CULTURE TO INCLUDE ARTS-BASED THERAPIES, COORDINATION WITH LOCAL HOUSES OF WORSHIP AND SPIRITUAL-BASED HEALING. IN ADDITION, AFTER PROJECT HOPE CRISIS COUNSELING SERVICES (FEMA-4480-DR-NY) END ON DECEMBER 12, 2022, THE BUFFALO URBAN LEAGUE AND SPECTRUM HEALTH WILL PARTICIPATE IN RECAST TO CONTINUE DELIVERING NYS OMH IN-KIND CRISIS COUNSELING OUTREACH AND ENGAGEMENT SERVICES TO BLACK/AFRICAN AMERICAN FAMILIES AND YOUTH RESIDING IN OR ATTENDING SCHOOLS IN THE EAST SIDE. TRAINING IN TRAUMA-INFORMED CARE AND APPROACHES WILL BE PROVIDED IN -KIND THROUGH THE NYS TRAUMA-INFORMED NETWORK AND VIA INDVIDUALS IN THE COMMUNITY TRAINED BY THE NYS OMH SERG PSYCHOLOGICAL FIRST AID TRAIN-THE-TRAINER. RECAST FUNDING IS REQUESTED FOR YOUTH AND FAMILY PEER SERVICES THAT WILL BE INTEGRATED INTO THIS WORK. GIVEN THE SHORTAGE OF BLACK/AFRICAN AMERICAN YOUTH AND FAMILY PEER ADVOCATES IN BUFFALO, NYS OMH WILL PARTNER WITH PEER-RUN ORGANIZATIONS TO BUILD WORKFORCE PIPELINES FOR BLACK/AFRICAN AMERICAN FAMILIES AND YOUTH TO BECOME CREDENTIALED. THE PROPOSED RECAST PROJECT GOALS ARE: GOAL 1: BUILD A COMMUNITY COALITION REPRESENTING BUFFALO'S BLACK/AFRICAN AMERICAN COMMUNITY THAT IS EMPOWERED TO ASSESS AND PLAN FOR HIGH-RISK YOUTH AND FAMILIES IMPACTED BY THE MASS SHOOTING. GOAL 2: INCREASE LOCAL MH CAPACITY FOR TRAUMA-INFORMED AND CULTURALLY COMPETENT BEHAVIORAL HEALTH SERVICES, INCLUDING YOUTH AND FAMILY PEER SERVICES, IN BUFFALO'S EAST SIDE THROUGH TRADITIONAL WELLNESS APPROACHES IN SCHOOLS AND THE COMMUNITY. GOAL 3: INCREASE ACCESS TO TRAUMA-INFORMED TRAINING TO EMPOWER LOCAL COMMUNITY TO RESPOND TO NEEDS OF BLACK/AFRICAN AMERICAN YOUTH FAMILIES, AND COMMUNITY MEMBERS IN A TRAUMA-INFORMED AND CULTURALLY COMPETENT MANNER. EACH RECAST GOAL HAS A SET OF MEASURABLE OBJECTIVES IDENTIFIED BY TIMEFRAMES. WE ESTIMATE THAT APPROXIMATELY 3,806 UNDUPLICATED INDIVIDUALS WILL BE SERVED DURING THE FOUR YEARS OF THE PROJECT. Y1-370; Y2-967; Y3-1,242; Y4-1,227; TOTAL 3,806

2000000.00

0.00

0.00

2025-04-07

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Department of Health and Human Services

CONTRIBUTION OF MATERNAL IMMUNE ACTIVATION, VIRAL INFECTION AND EPIGENETICS TO AUTISM--A COMMUNITY-BASED CASE CONTROL STUDY - PROJECT SUMMARY/ABSTRACT AUTISM SPECTRUM DISORDER (ASD) IS A BROAD RANGE OF RELATED NEURODEVELOPMENTAL DISORDERS THAT ARE EXPRESSED WITHIN THE FIRST 2 TO 3 YEARS OF LIFE AS STEREOTYPIC BEHAVIORS, AND LANGUAGE AND SOCIAL-EMOTIONAL IMPAIRMENTS. ASD AFFECTS ABOUT 1 IN 59 CHILDREN IN THE UNITED STATES AND CARRIES A HIGH ECONOMIC COST TO FAMILIES AND COMMUNITIES. WHILE THERE IS A CONTRIBUTION OF HEREDITY, A GROWING BODY OF RESEARCH SUGGESTS THAT ASD HAS ORIGINS IN UTERO. SPECIFICALLY, EVIDENCE IS ACCUMULATING THAT PRENATAL INFLAMMATION IS A CRITICAL EXPOSURE IN THE CAUSAL PATHWAY OF AT LEAST A SUBSET OF ASD. NOTABLY, THIS EXPOSURE MAY OPERATE THROUGH SEX-DIMORPHIC EFFECTS ON THE PLACENTA ON FETAL BRAIN DEVELOPMENT, CONSISTENT WITH THE HIGH ASD RISK FOR MALES RELATIVE TO FEMALES. IN OUR COMMUNITY-BASED HOSPITAL POPULATION, UNIQUE DUE TO MANDATED UNIVERSAL PLACENTAL HISTOPATHOLOGY ASSESSMENT AND LINKAGE TO PEDIATRIC COMMUNITY CARE, PILOT ANALYSES IDENTIFIED A 3-TO-7-FOLD INCREASED RISK OF CHILDHOOD ASD ASSOCIATED WITH PRENATAL EXPOSURE TO ACUTE AND/OR CHRONIC INFLAMMATION (AI, CI). THIS MARKER WAS SEEN IN ~25% OF LOW-RISK CHILDREN EVENTUALLY DIAGNOSED WITH ASD. THESE INFLAMMATORY PLACENTAL PATHOLOGIES WERE NOT MARKED BY ANY MATERNAL SIGNS OR SYMPTOMS DURING PREGNANCY. IN ADDITION, WE IDENTIFIED A 13-FOLD INCREASED ODDS OF ASD RISK WITH PLACENTAL VILLOUS MALDEVELOPMENT (PVM). WE PROPOSE HERE TO TEST PATHWAYS FROM THESE PLACENTAL HISTOPATHOLOGY DIAGNOSES TO EVENTUAL ASD DIAGNOSIS. WE WILL BEGIN WITH TARGETED FORMALIN-FIXED PARAFFIN-EMBEDDED (FFPE) PLACENTAL HISTOPATHOLOGY OF AI, CI, AND PVM. WE WILL THEN EMPLOY DETAILED AND QUANTITATIVE IMMUNOPHENOTYPING OF PLACENTAL-DECIDUAL TISSUE AT THE PLACENTAL-MATERNAL INTERFACE. WE CAN THOROUGHLY PROFILE CELL TYPE, CELL FUNCTION MARKERS, AND INFLAMMATION ACTIVATION/APOPTOSIS TARGETS AT THE SAME TIME BY USING COMPUTER-ASSISTED DEEP LEARNING THAT ALLOWS PRECISE TRACKING OF IMMUNOLABELING AND MINIMIZES CONCERNS OF LABEL OVERLAP THAT CAN CONFOUND INTERPRETATION OF IMMUNOFLUORESCENT PREPARATIONS. WE WILL NEXT ASSESS NEWBORN CIRCULATING LEVELS OF CYTOKINES, CHEMOKINES, AND GROWTH FACTORS, ALTERATIONS OF WHICH ARE KNOWN TO IMPACT NEURODEVELOPMENTAL PROCESSES KEY TO THE GENESIS OF NEURONAL DYSFUNCTION MANIFESTED IN ASD. WE WILL ALSO EXAMINE EPIGENETIC PATHWAYS BY ASSESSING DNA METHYLATION IN THE PLACENTA AND ITS LINK TO INFLAMMATION AND PVM. OUR ANALYSES WILL TEST THESE AS PATHWAYS FROM PLACENTAL/DECIDUAL TISSUE MARKERS OF INFLAMMATION AND/OR PVM TO ASD DIAGNOSIS. NO OTHER ASD CASE-CONTROL SAMPLE IN A COMMUNITY-BASED POPULATION HAS UNIVERSAL ACCESS TO FFPE TISSUE. THIS PROPOSED PROJECT WILL OPEN A UNIQUE WINDOW ON THE PRENATAL ENVIRONMENT UNDERLYING ASD. CLARIFICATION OF THE PATHWAYS OPERATING IN COMMUNITY-BASED ASD WILL ELUCIDATE THE MECHANISMS INVOLVED IN ASD RISK.

1777022.00

0.00

0.00

2025-04-09

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Department of Health and Human Services

SYNAPTIC ACTIONS OF AMPHETAMINE IN THE STRIATUM - PROJECT SUMMARY ADDICTIVE PSYCHOSTIMULANTS SUCH AS AMPHETAMINE ACT AT DOPAMINE SYNAPSES IN THE STRIATUM. PRESYNAPTIC AMPHETAMINE ACTION DRIVES DOPAMINE RELEASE VIA ACTIVITY-DEPENDENT AND ACTIVITY-INDEPENDENT MECHANISMS. DOPAMINE ACTS ON MULTIPLE DOPAMINE RECEPTORS THAT ARE DIFFERENTIALLY DISTRIBUTED ON STRIATAL NEURONS. BEYOND THIS VOLUME TRANSMISSION, DOPAMINE NEURONS ENGAGE IN SYNAPTIC TRANSMISSION THAT IS OPERATIVE ON A FAST TIME SCALE, COMPARED TO VOLUME TRANSMISSION, AND INVOLVES NOT ONLY DOPAMINE, BUT ALSO GABA AND GLUTAMATE. THIS PROJECT FOCUSES ON THESE SYNAPTIC CONNECTIONS AS A NOVEL SUBSTRATE FOR PSYCHOSTIMULANT ACTION. THE SYNAPTIC TRANSMISSION EXERTS EXCITATORY EFFECTS THROUGH DOPAMINE D1 RECEPTORS, IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS, AND INHIBITORY EFFECTS THROUGH DOPAMINE D2 RECEPTORS AND GABAA RECEPTORS. WHILE DOPAMINERGIC AND GABAERGIC SYNAPTIC CONNECTIONS ARE WIDESPREAD, GLUTAMATERGIC CONNECTIONS ARE CONCENTRATED IN THE MEDIAL NUCLEUS ACCUMBENS AND THE ANTERIOR LATERAL DORSAL STRIATUM. SYNAPTIC CONNECTIONS TO CHOLINERGIC INTERNEURONS ARE THE STRONGEST, MOST COMPLEX, INVOLVING DOPAMINE, GABA AND GLUTAMATE. REMARKABLY GLUTAMATE COTRANSMISSION IS ABROGATED BY AMPHETAMINE ADMINISTRATION, AND ABROGATION OF GLUTAMATE COTRANSMISSION ATTENUATES PSYCHOSTIMULANT RESPONSIVENESS. THE GUIDING HYPOTHESIS IS THAT AMPHETAMINE- INDUCED PLASTICITY OF A SUBSET OF DOPAMINE NEURON SYNAPSES IS CRITICAL FOR DRIVING THE STRIATAL CIRCUITRY TOWARDS THE ADDICTED STATE, PARTICULARLY DOPAMINE NEURON SYNAPSES DISTINGUISHED BY GLUTAMATE COTRANSMISSION. THE THREE SPECIFIC AIMS ARE TO: <1> DETERMINE QUANTITATIVELY AMPHETAMINE-INDUCED PLASTICITY OF DOPAMINE NEURON SYNAPTIC CONNECTIONS TO CHOLINERGIC INTERNEURONS IN STRIATAL SUBREGIONS IDENTIFIED BY SYNAPTIC CONNECTIVITY-BASED CLUSTERING. <2> DETERMINE DIRECT SYNAPTIC EFFECTS OF AMPHETAMINE ON DOPAMINE NEURON SYNAPTIC TRANSMISSION IN STRIATAL SUBREGIONS DISTINGUISHED BY GLUTAMATE COTRANSMISSION. <3> DETERMINE AMPHETAMINE EFFECTS ON DOPAMINE NEURON TERMINAL ACTIVITY DURING AMPHETAMINE-INDUCED BEHAVIORS. THIS PROJECT WILL ADVANCE UNDERSTANDING OF THE SYNAPTIC SUBSTRATE OF AMPHETAMINE ACTION IN THE STRIATUM, REVEALING LOCI OF DRUG-INDUCED PLASTICITY THAT WILL INFORM THE PHARMACOTHERAPY OF ADDICTION.

1661845.00

0.00

0.00

2025-03-24

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Department of Health and Human Services

A MULTI-LEVEL APPROACH TO IMPROVE HIV PREVENTION AND CARE FOR TRANSGENDER WOMEN OF COLOR - ABSTRACT IN THE UNITED STATES, TRANSGENDER (`TRANS') WOMEN HAVE HIGH RATES OF NEW HIV DIAGNOSES, WITH BLACK, LATINA, AND OTHER TRANS WOMEN OF COLOR REPRESENTING THE MAJORITY OF THESE CASES. THE HIV PREVENTION AND CARE CONTINUA EMPHASIZE THE NEED FOR REDUCING HIV TRANSMISSION RISK VIA REGULAR HIV TESTING, CONSISTENT CONDOM USE, AND LINKAGES TO HIV PREVENTION AND CARE, SUCH AS PRE-EXPOSURE PROPHYLAXIS (PREP) AMONG HIV-NEGATIVE INDIVIDUALS AND ANTIRETROVIRAL THERAPY (ART) AND VIRAL SUPPRESSION AMONG PEOPLE LIVING WITH HIV. HOWEVER, THERE IS SUBSTANTIAL DROP-OFF AT EACH STEP OF THESE CONTINUA WITH TRANS WOMEN FALLING FAR BEHIND IN TERMS OF PREP USE AND VIRAL SUPPRESSION. TRANS WOMEN OF COLOR EXPERIENCE INTERSECTIONAL STIGMA THAT RESULTS IN UNMET GENDER AFFIRMATION NEEDS, WHICH HAVE BEEN LINKED TO DISPARITIES IN HIV PREVENTION AND CONTINUA OUTCOMES. BUILDING ON EXTENSIVE FORMATIVE WORK, THIS PROJECT SEEKS TO TEST THE EFFICACY OF THE LET’S BE INTERVENTION, WHICH IS AN INTEGRATION OF EVIDENCE-BASED, TRAUMA-INFORMED HIV PREVENTION AND TREATMENT INTERVENTIONS, ALL OF WHICH HAVE DEMONSTRATED FEASIBILITY, ACCEPTABILITY, AND PRELIMINARY EFFICACY WITH TRANS WOMEN. LET’S BE IS AN HIV STATUS- NEUTRAL INTERVENTION DESIGNED TO MITIGATE THE ADVERSE HEALTH SEQUELAE OF INTERSECTIONAL STIGMA (INCLUDING HIV STIGMA) THEREBY REDUCING SEXUAL RISK BEHAVIORS, INCREASING HIV PREVENTION UPTAKE (PREP USE), AND TREATMENT OUTCOMES (VIRAL SUPPRESSION). LET’S BE WORKS AT BOTH THE GROUP- AND INDIVIDUAL-LEVELS, COMPRISING TWO PEER-LED COMPONENTS VIA TELEHEALTH: 1) THE PREVIOUSLY TESTED SHEROES STATUS-NEUTRAL INTERVENTION, AND 2) PREVIOUSLY TESTED INDIVIDUAL-LEVEL PEER NAVIGATION ADAPTED FROM THE HEALTHY DIVAS INTERVENTION. WE PROPOSE A HYBRID TYPE 1 EFFECTIVENESS-IMPLEMENTATION STUDY FOCUSED PRIMARILY ON TESTING THE EFFICACY OF LET’S BE, WHILE SECONDARILY BUT SIMULTANEOUSLY GLEANING IMPORTANT LESSONS DURING IMPLEMENTATION. OUR PRIMARY OUTCOME IS PREP ADHERENCE/VIRAL SUPPRESSION AND OUR SECONDARY OUTCOME IS A COMPOSITE INDICATOR OF HIV RISK THAT ACKNOWLEDGES THERE IS NOT A SINGULAR EFFECTIVE PREVENTION STRATEGY THAT IS APPROPRIATE OR DESIRED BY ALL TRANSGENDER WOMEN. WE WILL RECRUIT AND RANDOMIZE 250 TRANS WOMEN OF COLOR FROM SAN FRANCISCO, CALIFORNIA AND DETROIT, MICHIGAN (STRATIFIED BY CITY AND HIV STATUS), FOLLOWING PARTICIPANTS FOR 12 MONTHS AND COLLECTING BIOLOGICAL (I.E., DRIED BLOOD SPOTS TO MEASURE PREP USE OR VIRAL LOAD) AND BEHAVIORAL DATA. OUR COMMUNITY ADVISORY BOARDS COMPOSED OF TRANS WOMEN OF COLOR WILL PROVIDE ONGOING CONSULTATION. OUR HYBRID TYPE 1 EFFECTIVENESS-IMPLEMENTATION DESIGN WILL INFORM IMPLEMENTATION CONSIDERATIONS TO SCALE UP LET’S BE TO OTHER EHE JURISDICTIONS, IF EFFECTIVE. FINDINGS WILL PROVIDE CRITICAL INSIGHTS INTO THE EFFICACY EVALUATION OF AN URGENTLY NEEDED TRAUMA-INFORMED MULTI-LEVEL STATUS-NEUTRAL INTERVENTION DELIVERED VIA TELEHEALTH IN REDUCING DISPARITIES AMONG TRANS WOMEN OF COLOR, ONE OF THE HIGHEST PRIORITY HIV PREVENTION POPULATIONS IN THE UNITED STATES.

1132843.00

0.00

0.00

2025-04-14

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Department of Health and Human Services

CANNABIS USE PATTERNS AND ASSOCIATIONS WITH COGNITIVE IMPAIRMENT IN OLDER ADULTS - PROJECT SUMMARY/ABSTRACT SIGNIFICANCE. CANNABIS USE IS INCREASING EXPONENTIALLY AMONG OLDER US ADULTS (≥65 YEARS), A POPULATION THAT IS EXPECTED TO COMPRISE OVER 20% OF THE POPULATION IN COMING DECADES. OLDER ADULTS ARE PARTICULARLY VULNERABLE TO COGNITIVE IMPAIRMENT ASSOCIATED WITH CANNABIS USE, AND DEMONSTRATE INCREASINGLY HETEROGENEOUS PATTERNS OF CANNABIS USE (INCLUDING CANNABIS USE HISTORIES AND CURRENT USE PROFILES). CONSEQUENTLY, THIS RAPIDLY GROWING POPULATION OF CANNABIS USERS WILL BECOME A PUBLIC HEALTH CONCERN IN COMING YEARS AND MERIT PREVENTIVE AND THERAPEUTIC INTERVENTIONS. EXTANT INFORMATION ON CANNABIS USE PATTERNS AND THEIR ASSOCIATIONS WITH COGNITIVE IMPAIRMENT IS LACKING IN THIS CRITICALLY UNDERSTUDIED POPULATION. THIS RESEARCH PROPOSAL EXAMINES ASSOCIATIONS BETWEEN A RANGE OF CANNABIS USE MEASURES AND COGNITIVE IMPAIRMENT, PARTICULARLY RESIDUAL IMPAIRMENT (I.E., COGNITIVE EFFECTS OBSERVED AFTER ACUTE INTOXICATION HAS PASSED), IN OLDER ADULT CANNABIS USERS. CAREER DEVELOPMENT PLAN. DR. LIVNE’S TRAINING PROGRAM WILL INCLUDE COURSEWORK AND MENTORSHIP TO DEVELOP HIS SKILLS AND EXPERTISE IN SURVEY DESIGN, AGING AND COGNITION-RELATED RESEARCH, AND GENERALIZED LINEAR MODELING, CAUSAL MODELING AND LONGITUDINAL ANALYSES. THESE ARE NECESSARY FOR ACHIEVING HIS CAREER GOALS OF BECOMING AN INDEPENDENT INVESTIGATOR PERFORMING IMPACTFUL RESEARCH ON THE INTERSECTION BETWEEN CANNABIS USE, COGNITION, AND THE AGING POPULATION. MENTORSHIP. DR. LIVNE’S WILL BE SUPPORTED BY A HIGHLY ACCOMPLISHED TEAM OF MENTORS WHO ARE EXPERTS IN SUBSTANCE USE EPIDEMIOLOGY, BIOSTATISTICS, AGING, AND COGNITION. RESEARCH PLAN. FOR AIM 1, DR. LIVNE WILL USE DATA FROM THE HEALTH AND RETIREMENT STUDY, A LARGE NATIONALLY REPRESENTATIVE STUDY OF OLDER US ADULTS, TO EXAMINE ASSOCIATIONS BETWEEN CANNABIS USE PREDICTORS AND DOMAIN-SPECIFIC COGNITIVE IMPAIRMENT, INCLUDING RESIDUAL IMPAIRMENT, AMONG ADULTS ≥65 YEARS. FOR AIM 2A, DR. LIVNE WILL RECRUIT A LARGE ONLINE SAMPLE OF OLDER ADULTS VIA SOCIAL MEDIA PLATFORMS, TO DESCRIBE CANNABIS USE PATTERNS (I.E., CANNABIS USE HISTORIES, CURRENT PROFILES OF USE) AND EXAMINE THE ASSOCIATIONS BETWEEN SUCH PATTERNS. FOR AIM 2B, DR. LIVNE WILL CONDUCT A PILOT STUDY OF A SUBSET OF RESPONDENTS FROM THE ONLINE SAMPLE AS WELL AS SOCIODEMOGRAPHICALLY COMPARABLE OLDER ADULTS WITH NO LIFETIME CANNABIS USE. USING SELF-ADMINISTERED NEUROPSYCHOLOGICAL ASSESSMENTS, HE WILL ASSESS THE FEASIBILITY OF INTEGRATING COGNITIVE TESTS IN ONLINE SAMPLES OF OLDER ADULTS AND PROVIDE PRELIMINARY DATA ON ASSOCIATIONS BETWEEN DETAILED MEASURES OF CANNABIS USE PATTERNS AND DOMAIN-SPECIFIC RESIDUAL COGNITIVE IMPAIRMENT, EXPANDING ON ANALYSES FROM AIM 1. PUBLIC HEALTH IMPACT. THIS PROJECT WILL ILLUMINATE PATTERNS OF CANNABIS USE AND ASSOCIATED COGNITIVE IMPAIRMENT AMONG OLDER ADULTS, THUS INFORMING CLINICIANS, RESEARCHERS, AND POLICYMAKERS OF INDIVIDUAL AND PUBLIC HEALTH RISKS IN A GROWING YET UNDERSTUDIED CANNABIS USER POPULATION. SUBSEQUENTLY, FINDINGS WILL INFORM THE DEVELOPMENT OF HARM REDUCTION STRATEGIES AND THE FEASIBILITY OF UTILIZING ONLINE RESEARCH TOOLS FOR COST-EFFECTIVE COGNITIVE ASSESSMENT OF OLDER ADULT SUBSTANCE USERS.

390644.00

0.00

0.00

14-1410842

Government Instrumentality, Title-Holding Corporation, Charitable Organization, Agricultural Organization, Board of Trade, Pleasure, Recreational, or Social Club, Fraternal Beneficiary Society, Order or Association, Voluntary Employees' Beneficiary Association (Non-Govt. Emps.), Domestic Fraternal Societies and Associations, Teachers Retirement Fund Assoc., Benevolent Life Insurance Assoc., Burial Association, Credit Union, Mutual Insurance Company or Assoc. Other Than Life or Marine, Corp. Financing Crop Operations, Supplemental Unemployment Compensation Trust or Plan, Employee Funded Pension Trust (Created Before 6/25/59), Post or Organization of War Veterans, Legal Service Organization, Black Lung Trust, Multiemployer Pension Plan, Veterans Assoc. Formed Prior to 1880, Trust Described in Sect. 4049 of ERISA, Title Holding Co. for Pensions, etc., State-Sponsored High Risk Health Insurance Organizations, State-Sponsored Workers' Compensation Reinsurance, ACA 1322 Qualified Nonprofit Health Insurance Issuers, Apostolic and Religious Org. (501(d)), Cooperative Hospital Service Organization (501(e)), Cooperative Service Organization of Operating Educational Organization (501(f)), Child Care Organization (501(k)), Charitable Risk Pool, Qualified State-Sponsored Tuition Program, 4947(a)(1) - Private Foundation (Form 990PF Filer)

1954-05

Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)